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Simultaneous β1 integrin-EGFR targeting and radiosensitization of human head and neck cancer.
BACKGROUND Signaling from integrins and receptor tyrosine kinases (RTKs) contributes substantially to therapy resistance of malignant tumors. We investigated simultaneous β1 integrin-epidermal growthExpand
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Efficacy of Beta1 Integrin and EGFR Targeting in Sphere-Forming Human Head and Neck Cancer Cells
Background: Resistance to radiotherapy continues to be a limiting factor in the treatment of cancer including head and neck squamous cell carcinoma (HNSCC). Simultaneous targeting of β1 integrin andExpand
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Neuregulin-1, the fetal endothelium, and brain damage in preterm newborns
OBJECTIVE To assess the potential role for Neuregulin-1 (NRG1) as a systemic endogenous protector in the setting of perinatal inflammatory brain damage. METHODS We measured NRG1-protein and mRNAExpand
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EGFR and β1-integrin targeting differentially affect colorectal carcinoma cell radiosensitivity and invasion.
BACKGROUND AND PURPOSE Simultaneous targeting of β1 integrin receptor and epidermal growth factor receptor (EGFR) showed higher level of radiosensitization in head and neck cancers thanExpand
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Single-domain antibodies: Next-generation targeting vectors for molecular imaging
Results: Tc-1 and Tc-2 exhibited high specific FR binding in vitro. Both Tc-1 and Tc-2 displayed high tumor uptake (8.55 ± 2.78% ID/g and 9.77 ± 1.54% ID/g at 1 h p.i., respectively) and rapidExpand
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Corrigendum to “Neuregulin-1, the fetal endothelium, and brain damage in preterm newborns” [Brain Behav. Immun. 24 (2010) 784–791]
In the original publication, the wrong antibodies were listed in the section ‘‘Methods and patients; 2.4. ELISA’’. All experiments were performed using the R&D DuoSet ELISA Kit which includes theExpand
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