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Ochratoxin A from a toxicological perspective.
Arguments are presented which suggest an acceptable daily intake (ADI) of 1.5 ng OTA/kg body weight and a much lower MRL than 5 microgram Ota/kg cereals and cereal products as has been postulated by the EU commission.
The transport of bile acids in liver cells.
Conformational Prerequisites for the in vitro Inhibition of Cholate Uptake in Hepatocytes by Cyclic Analogues of Antamanide and Somatostatin
Tissue-selective action of pravastatin due to hepatocellular uptake via a sodium-independent bile acid transporter.
Azidobenzamido-008, a new photosensitive substrate for the 'multispecific bile acid transporter' of hepatocytes: evidence for a common transport system for bile acids and cyclosomatostatins in…
Determination of the apparent functional molecular mass of the hepatocellular sodium-dependent taurocholate transporter by radiation inactivation.
ATP-dependent transport of the linear renin-inhibiting peptide EMD 51921 by canalicular plasma membrane vesicles of rat liver: evidence of drug-stimulatable ATP-hydrolysis.
Inhibition of 3H-demethylphalloin uptake in isolated rat hepatocytes under various experimental conditions
- E. Petzinger, K. Ziegler, M. Frimmer
- Biology, MedicineNaunyn-Schmiedeberg's Archives of Pharmacology
- 1 July 1979
The results confirm the working hypothesis, presented in several previous papers, that decreased sensitivity to phalloidin is probably due to a reduced or blocked uptake of the toxin.
Hepatobiliary elimination of certain peptide-mimicking drugs: linear hydrophobic and hydrophilic renin-inhibitors and hydrophobic cyclopeptides.
Kinetic investigations on the hepatocellular uptake of certain peptide-mimicking drugs revealed that in most cases carrier-mediated mechanisms are responsible for their rapid extraction from portal…