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Genome-wide methylation profiles reveal quantitative views of human aging rates.
The ability to measure human aging from molecular profiles has practical implications in many fields, including disease prevention and treatment, forensics, and extension of life. AlthoughExpand
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Identifying Medical Diagnoses and Treatable Diseases by Image-Based Deep Learning
The implementation of clinical-decision support algorithms for medical imaging faces challenges with reliability and interpretability. Here, we establish a diagnostic tool based on a deep-learningExpand
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A Variant of the HTRA1 Gene Increases Susceptibility to Age-Related Macular Degeneration
Age-related macular degeneration (AMD) is the most common cause of irreversible vision loss in the developed world and has a strong genetic predisposition. A locus at human chromosome 10q26 affectsExpand
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Drusen complement components C3a and C5a promote choroidal neovascularization.
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in industrialized nations, affecting 30-50 million people worldwide. The earliest clinical hallmark of AMD is theExpand
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Vascular Development in the Retina and Inner Ear Control by Norrin and Frizzled-4, a High-Affinity Ligand-Receptor Pair
Incomplete retinal vascularization occurs in both Norrie disease and familial exudative vitreoretinopathy (FEVR). Norrin, the protein product of the Norrie disease gene, is a secreted protein ofExpand
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Direct reprogramming of mouse fibroblasts to neural progenitors
  • J. Kim, J. Efe, +6 authors S. Ding
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 26 April 2011
The simple yet powerful technique of induced pluripotency may eventually supply a wide range of differentiated cells for cell therapy and drug development. However, making the appropriate cells viaExpand
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Reprogramming of human primary somatic cells by OCT4 and chemical compounds.
Induced pluripotent stem cell (iPSC) technology, i.e. reprogramming somatic cells into pluripotent cells that closely resemble embryonic stem cells (ESCs) by introduction of defined transcriptionExpand
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Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors
  • W. Li, W. Sun, +11 authors S. Ding
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 27 April 2011
Human embryonic stem cells (hESCs) hold enormous promise for regenerative medicine. Typically, hESC-based applications would require their in vitro differentiation into a desirable homogenous cellExpand
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Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated MicroRNA Circuits
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a singleExpand
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A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy
Stargardt-like macular dystrophy (STGD3, MIM 600110) and autosomal dominant macular dystrophy (adMD) are inherited forms of macular degeneration characterized by decreased visual acuity, macularExpand
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