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Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases
It is demonstrated that miRNAs are present in the serum and plasma of humans and other animals such as mice, rats, bovine fetuses, calves, and horses, and can serve as potential biomarkers for the detection of various cancers and other diseases. Expand
Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA
It is shown that MIR168a could bind to the human/mouse low-density lipoprotein receptor adapter protein 1 (LDLRAP1) mRNA, inhibit LDLRAP1 expression in liver, and consequently decrease LDL removal from mouse plasma, demonstrating that exogenous plant miRNAs in food can regulate the expression of target genes in mammals. Expand
Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance
Identification of the molecules associated with the dynamic changes of macrophage polarization and understanding their interactions is crucial for elucidating the molecular basis of disease progression and designing novel macrophages-mediated therapeutic strategies. Expand
Secreted monocytic miR-150 enhances targeted endothelial cell migration.
It is reported that secreted miRNAs can serve as signaling molecules mediating intercellular communication and demonstrate that cells can secrete miRNA and deliver them into recipient cells where the exogenous mi RNAs can regulate target gene expression and recipient cell function. Expand
Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer.
- Zhibin Hu, X. Chen, +8 authors Hongbing Shen
- Biology, Medicine
- Journal of clinical oncology : official journal…
- 1 April 2010
The four-miRNA signature from the serum may serve as a noninvasive predictor for the overall survival of NSCLC. Expand
Serum microRNA profiles serve as novel biomarkers for HBV infection and diagnosis of HBV-positive hepatocarcinoma.
This study demonstrates for the first time that serum miRNA profiles can serve as novel and noninvasive biomarkers for HBV infection and HBV-positive HCC diagnosis. Expand
Secreted microRNAs: a new form of intercellular communication.
- X. Chen, Hongwei Liang, Junfeng Zhang, K. Zen, Chen-Yu Zhang
- Biology, Medicine
- Trends in cell biology
- 1 March 2012
A possible working model for how secreted miRNAs might be sorted and transferred between cells are proposed and speculated on their biological significance are proposed. Expand
Identification and characterization of microRNAs in raw milk during different periods of lactation, commercial fluid, and powdered milk products
It is demonstrated for the first time that cow milk contains large amounts of microRNAs (miRNAs) and that the unique expression profile of milk-specific miRNAs can serve as a novel indicator and possible new standard for the quality control of raw milk and milk-related commercial products, such as fluid milk and powdered formula milk. Expand
Honeysuckle-encoded atypical microRNA2911 directly targets influenza A viruses
It is reported that MIR2911, a honeysuckle-encoded atypical microRNA, directly targets IAVs with a broad spectrum and may represent a novel type of natural product that effectively suppresses viral infection. Expand
Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial coxsackie and adenovirus receptor and a junctional adhesion molecule-like protein on neutrophils.
Evidence is provided that PMN-expressed junctional adhesion molecule-like protein (JAML) regulates transmigration via binding interactions with epithelial coxsackie and adenovirus receptor (CAR) and in assays of PMN transepithelial migration, JAML/CAR fusion proteins and their antibodies significantly inhibited transmigration in a specific manner. Expand