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Near completely humanized liver in mice shows human-type metabolic responses to drugs.
TLDR
It is concluded that the chimeric mouse developed in the present study is a useful model for assessing the functions and pharmacological responses of human hepatocytes. Expand
Characterization of a Stellate Cell Activation-associated Protein (STAP) with Peroxidase Activity Found in Rat Hepatic Stellate Cells*
TLDR
Results indicate that STAP is a novel endogenous peroxidase catabolizing hydrogen peroxide and lipid hydroperoxides, both of which have been reported to trigger stellate cell activation and consequently promote progression of liver fibrosis and could thus play a role as an antifibrotic scavenger of peroxides in the liver. Expand
MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis
TLDR
Among these miRNAs, miR-221/222 were upregulated in LX-2 cells and increased during the course of culture-dependent activation of mouse primary stellate cells, in a manner similar to the expression of α1(I) collagen and α-smooth muscle actin mRNAs. Expand
Cytoglobin/STAP, its unique localization in splanchnic fibroblast-like cells and function in organ fibrogenesis
TLDR
Results indicate that Cygb/STAP is a tissue globin uniquely localized in splanchnic fibroblastic cell lineage and may play a role in fibrotic organ disorder. Expand
Transgenic silkworms produce recombinant human type III procollagen in cocoons
TLDR
The viability of transgenic silkworms as a tool for producing useful proteins in bulk is demonstrated by immunoblotting, collagenase-sensitivity tests, and amino acid sequencing. Expand
Structural basis of human cytoglobin for ligand binding.
TLDR
In the crystal structure, ferric Cgb is dimerized through two intermolecular disulfide bonds between Cys38(B2) and Cys83(E9), and the dimerization interface is similar to that of lamprey Hb and Ngb, while the overall backbone structure of the Cgb monomer exhibits a traditional globin fold with a three-over-three alpha-helical sandwich. Expand
The generation of germline transgenic silkworms for the production of biologically active recombinant fusion proteins of fibroin and human basic fibroblast growth factor.
TLDR
It was concluded that the worms spun cocoons whose Fibroin layers were composed of the inherent gene-derived natural fibroin (nF) and r(FL/bFGF), which will be suitable for mass production of fibroins bearing a variety of biological activities. Expand
Suppression of type I collagen production by microRNA-29b in cultured human stellate cells.
TLDR
Results suggested that miR-29b is involved in the regulation of type I collagen expression by interferon-alpha in hepatic stellate cells and is anticipated that it will be used for theregulation of stellates cell activation and lead to antifibrotic therapy. Expand
Proteome analysis of rat hepatic stellate cells
TLDR
Northern blots confirmed up‐regulation of the messenger RNAs (mRNAs) of calcyclin, calgizzarin, and galectin‐1 in activated stellate cells, indicating that these changes were controlled at the mRNA level. Expand
Suppression of hepatic stellate cell activation by microRNA-29b.
TLDR
Results suggested that miR-29b is involved in the activation of HSCs and could be a candidate molecule for suppressing their activation and consequent liver fibrosis. Expand
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