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Extended release of a large amount of highly water-soluble diltiazem hydrochloride by utilizing counter polymer in polyethylene oxides (PEO)/polyethylene glycol (PEG) matrix tablets.
The purpose of this study was to evaluate the feasibility of using a counter polymer in polyethylene oxide (PEO)/polyethylene glycol (PEG) polymeric matrices for the sustained release of a largeExpand
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Aminoalkyl methacrylate copolymers for improving the solubility of tacrolimus. I: Evaluation of solid dispersion formulations.
The aim of this study was to investigate the effect of Eudragit E/HCl (E-SD) on the reprecipitation of a poorly water-soluble drug, tacrolimus. To evaluate the inhibition of reprecipitation of E-SD,Expand
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Effect of aminoalkyl methacrylate copolymer E/ HCl on in vivo absorption of poorly water-soluble drug
This study aimed to investigate in vivo absorption of tacrolimus formulated as a solid dispersion using Eudragit E®/HCl (E-SD). E-SD is an aminoalkyl methacrylate copolymer that can be dissolvedExpand
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Timed-release formulation to avoid drug-drug interaction between diltiazem and midazolam.
The purpose of this study was to investigate whether the use of a timed-release (TR) drug formulation can avoid unfavorable pharmacokinetic drug-drug interactions in vivo. First, the effects of theExpand
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Binding Constants of Symmetric or Antisymmetric Electrolytes and Aggregation Numbers of Oil-in-Water Type Microemulsions with a Nonionic Surfactant
The effects of electrolytes (symmetric and antisymmetric) on the phase behavior, the apparent cloud point, the ζ-potential, the particle size, and the surface charge density of an oil-in-water typeExpand
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Oral sustained-release suspension based on a lauryl sulfate salt/complex.
The objective of this study was to evaluate the feasibility of lauryl sulfate (LS) salt/complex as a novel carrier in oral sustained-release suspensions. Mirabegron, which has a pH-dependentExpand
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Binding constants of calcium and/or magnesium electrolytes and aggregation numbers in oil-in-water type microemulsions formed by an amphoteric surfactant
The effects of anti-symmetric electrolytes (CaCl2, Ca(SCN)2, MgCl2, and/or Mg(SCN)2) and pH on the phase behavior, the ζ-potential, the hydrodynamic diameter and the surface charge density of anExpand
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Oral Sustained Release of a Hydrophilic Drug Using the Lauryl Sulfate Salt/Complex.
The objective of this study was to establish the key factor of the lauryl sulfate (LS) salt/complex for sustained release of a hydrophilic drug at various physiological pH levels. Mirabegron is aExpand
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Binding constants of inorganic electrolytes and aggregation numbers of oil-in-water-type microemulsions with an amphoteric surfactant
The pH dependence of the ζ-potential and the particle size of the oil-in-water (O/W) type (lower phase) microemulsion forming in solutions of N α ,N α -dimethyl-N e -lauroyllysineExpand
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Determination of binding constants of sodium and chloride ions and aggregation numbers of amphoteric surfactant microemulsions by a novel numerical analysis
Abstract The pH dependence of the -potential and the surface charge density of the O/W-type microemulsion forming in solutions of Nα,Nα-dimethyl-Ne-lauroyllysine (DMLL)/1-pentanol/n-octane/NaCI haveExpand
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