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Mineralocorticoid and glucocorticoid receptor expressions in astrocytes and microglia in the gerbil hippocampal CA1 region after ischemic insult
Enhanced MR and GR expressions in astrocytes and microglia were detected in the hippocampal CA1 region 4-7 days after ischemia/reperfusion. Expand
Ischemia‐induced changes in glucagon‐like peptide‐1 receptor and neuroprotective effect of its agonist, exendin‐4, in experimental transient cerebral ischemia
The results indicate that GLP‐1R is altered in the ischemic region after an isChemic insult and that EX‐4 protects against ischemia‐induced neuronal death possibly by increasing GLP-1R expression and attenuating microglial activation against transient cerebral ischeMIC damage. Expand
Extract from Terminalia chebula Seeds Protect Against Experimental Ischemic Neuronal Damage Via Maintaining SODs and BDNF Levels
The results indicate that the repeated supplement of TCE protected neurons from ischemic damage induced by transient cerebral ischemia by maintaining SODs and BDNF levels as well as decreasing glial activation. Expand
Reduced Cell Proliferation and Neuroblast Differentiation in the Dentate Gyrus of High Fat Diet-Fed Mice are Ameliorated by Metformin and Glimepiride Treatment
It is suggested that a HFD significantly reduces cell proliferation and neuroblast differentiation by reducing BDNF levels and these effects are ameliorated by treatment with met or met + glim. Expand
Zizyphus attenuates ischemic damage in the gerbil hippocampus via its antioxidant effect.
The results suggest that the repeated supplements of ZJE can protect neurons from ischemic damage via up-regulation of SOD1 and reduction of lipid peroxidation in the isChemic hippocampal CA1 region. Expand
Transduced human PEP‐1–heat shock protein 27 efficiently protects against brain ischemic insult
It is suggested that transduction of PEP‐1–HSP27 fusion protein provides a potential strategy for therapeutic delivery in various human diseases in which reactive oxygen species are implicated, including stroke. Expand
Berberry extract reduces neuronal damage and N-Methyl-D-aspartate receptor 1 immunoreactivity in the gerbil hippocampus after transient forebrain ischemia.
  • K. Yoo, I. Hwang, +6 authors M. Won
  • Biology, Medicine
  • Biological & pharmaceutical bulletin
  • 1 April 2006
The results suggest that BE has potent neuroprotective effects against ischemic damage via the reduction of NR1 activity. Expand
Ionized Calcium-binding Adapter Molecule 1 Immunoreactive Cells Change in the Gerbil Hippocampal CA1 Region after Ischemia/Reperfusion
Change morphologically and iba-1 immunoreactivity alters in the CA1 region with time after ischemia/reperfusion are observed, which may be associated with the delayed neuronal death of CA1 pyramidal cells in the gerbil ischemic hippocampus. Expand
Expression and changes of endogenous insulin-like growth factor-1 in neurons and glia in the gerbil hippocampus and dentate gyrus after ischemic insult
The results suggest that the induction of IGF-1 in the CA1 area during the early stage (12-24 h after ischemic insult) is associated with the relative vulnerabilities of pyramidal glutamatergic neurons and non-pyramidal GABAergic neurons, and the later increase (4 days after ischemia-reperfusion) of IGF -1 expression and protein content was found to promote the activities of astrocytes and microglia. Expand
Antiinflammatory effect of the ethanol extract of Berberis koreana in a gerbil model of cerebral ischemia/reperfusion
The potent neuroprotective effect of BE was found to be due to the inhibitions of COX‐2 expression and PGE2 production and its antiinflammatory activity. Expand