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Nanomaterials enhanced surface plasmon resonance for biological and chemical sensing applications.
The latest trend and challenges in engineering and applications of nanomaterials-enhanced surface plasmon resonance sensors for detecting "hard-to-identify" biological and chemical analytes are reviewed and discussed. Expand
Sensitivity Enhancement of Transition Metal Dichalcogenides/Silicon Nanostructure-based Surface Plasmon Resonance Biosensor
The results show that silicon nanosheet and MX2 layers can be served as effective light absorption medium under resonance conditions and show much better performance than that of the conventional sensing scheme where pure Au thin film is used. Expand
Imaging pancreatic cancer using bioconjugated InP quantum dots.
The successful use of non-cadmium-based quantum dots (QDs) as highly efficient and nontoxic optical probes for imaging live pancreatic cancer cells and the immense potential of InP/ZnS QDs in diagnostic imaging, particularly for early detection of cancer is suggested. Expand
Development of PEGylated PLGA nanoparticle for controlled and sustained drug delivery in cystic fibrosis
The therapeutic efficacy of nano-based proteostasis-modulator to rescue Pa-LPS induced CF lung disease is demonstrated and a novel drug delivery system to provide sustained delivery of CF "correctors" and "anti-inflammatories" to the lungs is developed. Expand
In vivo targeted cancer imaging, sentinel lymph node mapping and multi-channel imaging with biocompatible silicon nanocrystals.
This work overcomes dispersibility and functionalization challenges to in vivo imaging with Si QDs through a unique nanoparticle synthesis, surface functionalization, PEGylated micelle encapsulation, and bioconjugation process that produces bright, targeted nanospheres with stable luminescence and long tumor accumulation time in vivo. Expand
Graphene–MoS2 hybrid nanostructures enhanced surface plasmon resonance biosensors
Abstract In this work, we propose a new configuration of surface plasmon resonance (SPR) sensor that is based on graphene–MoS2 hybrid structures for ultrasensitive detection of molecules. TheExpand
Biocompatible luminescent silicon quantum dots for imaging of cancer cells.
This paper reports the preparation of highly stable aqueous suspensions of Si QDs using phospholipid micelles, in which the optical properties of Si nanocrystals are retained, which paves the way for silicon quantum dots to be a valuable optical probe in biomedical diagnostics. Expand
A pilot study in non-human primates shows no adverse response to intravenous injection of quantum dots.
It is shown in a pilot study that rhesus macaques injected with phospholipid micelle-encapsulated CdSe/CdS/ZnS quantum dots do not exhibit evidence of toxicity, and chemical analysis revealed that most of the initial dose of cadmium remained in the liver, spleen and kidneys after 90 days. Expand
MMP-9 gene silencing by a quantum dot–siRNA nanoplex delivery to maintain the integrity of the blood brain barrier
These studies promise the application of a novel nanoparticle based siRNA delivery system in modulating the MMP-9 activity in BMVECs and other M MP-9 producing cells to prevent neuroinflammation and maintain the integrity of the BBB. Expand
Enhancing the delivery of anti retroviral drug "Saquinavir" across the blood brain barrier using nanoparticles.
A significant enhancement in the transversing capability of QR-Tf-Saquinavir across the blood brain barrier, along with a marked decrease in HIV-1 viral replication in the PBMCs indicate that drug-loaded nanoparticles can deliver therapeutics across the BBB. Expand