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Involvement of cytochrome P‐450 isozymes in melatonin metabolism and clinical implications
To the Editor: The use of melatonin as a dietary supplement has increased significantly over the past few years, as reflected by its sales, which now exceed those of vitamin C in the United StatesExpand
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Preclinical pharmacokinetics and metabolism of BMS-214778, a novel melatonin receptor agonist.
BMS-214778 is a novel melatonin receptor agonist that may be a useful treatment for sleep disorders that result from disruption of circadian rhythms. Pharmacokinetic studies following intravenous andExpand
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Selective Inhibition of Eosinophil Influx into the Lung by Small Molecule CC Chemokine Receptor 3 Antagonists in Mouse Models of Allergic Inflammation
CC chemokine receptor (CCR) 3 is a chemokine receptor implicated in recruiting cells, particularly eosinophils (EΦ), to the lung in episodes of allergic asthma. To investigate the efficacy ofExpand
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THE CHIMPANZEE (PAN TROGLODYTES) AS A PHARMACOKINETIC MODEL FOR SELECTION OF DRUG CANDIDATES: MODEL CHARACTERIZATION AND APPLICATION
The chimpanzee (CHP) was evaluated as a pharmacokinetic model for humans (HUMs) using propranolol, verapamil, theophylline, and 12 proprietary compounds. Species differences were observed in theExpand
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Pharmacokinetics and oral bioavailability of exogenous melatonin in preclinical animal models and clinical implications
Yeleswaram K, McLaughlin LG, Knipe JO, Schabdach D. Pharmacokinetics and oral bioavailability of exogenous melatonin in preclinical animal models and clinical implications. J. Pineal Res. 1997;Expand
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The synthesis and characterization of BMS-204352 (MaxiPost) and related 3-fluorooxindoles as openers of maxi-K potassium channels.
3-Aryl-3-fluorooxindoles can be efficiently synthesized in two steps by the addition of an aryl Grignard to an isatin, followed by treatment with DAST. Oxindole 1 (BMS-204352; MaxiPost) can beExpand
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In vivo disposition and in vitro metabolism of an anxiolytic compound, BMS-184111, in rats.
Plasma concentrations of BMS-184111, an anxiolytic, were determined as a function of time following single intravenous, intraperitoneal and oral administrations. In order to assess the brainExpand
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Heterocyclic aminopyrrolidine derivatives as melatoninergic agents.
  • L. Sun, J. Chen, +13 authors G. Luo
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 6 April 2004
A series of chiral heterocyclic aminopyrrolidine derivatives was synthesized as novel melatoninergic ligands. Binding affinity assays were performed on cloned human MT(1) and MT(2) receptors, stablyExpand
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Relevance of tissue distribution studies.
  • K. Yeleswaram
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological…
  • 1 February 1995
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