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Taste Preference for Fatty Acids Is Mediated by GPR40 and GPR120
The oral perception of fat has traditionally been considered to rely mainly on texture and olfaction, but recent findings suggest that taste may also play a role in the detection of long chain fattyExpand
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Detection of Sweet and Umami Taste in the Absence of Taste Receptor T1r3
The tastes of sugars (sweet) and glutamate (umami) are thought to be detected by T1r receptors expressed in taste cells. Molecular genetics and heterologous expression implicate T1r2 plus T1r3 as aExpand
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Trpm5 null mice respond to bitter, sweet, and umami compounds.
Trpm5 is a calcium-activated cation channel expressed selectively in taste receptor cells. A previous study reported that mice with an internal deletion of Trpm5, lacking exons 15-19 encodingExpand
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Heat activation of TRPM5 underlies thermal sensitivity of sweet taste
TRPM5, a cation channel of the TRP superfamily, is highly expressed in taste buds of the tongue, where it has a key role in the perception of sweet, umami and bitter tastes. Activation of TRPM5Expand
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The taste transduction channel TRPM5 is a locus for bitter‐sweet taste interactions
Ordinary gustatory experiences, which are usually evoked by taste mixtures, are determined by multiple interactions between different taste stimuli. The most studied model for these gustatoryExpand
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Abnormal Taste Perception in Mice Lacking the Type 3 Inositol 1,4,5-Trisphosphate Receptor*
Inositol 1,4,5-trisphosphate receptor (IP3R) is one of the important calcium channels expressed in the endoplasmic reticulum and has been shown to play crucial roles in various physiologicalExpand
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Endocannabinoids selectively enhance sweet taste
Endocannabinoids such as anandamide [N-arachidonoylethanolamine (AEA)] and 2-arachidonoyl glycerol (2-AG) are known orexigenic mediators that act via CB1 receptors in hypothalamus and limbicExpand
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Discrimination of taste qualities among mouse fungiform taste bud cells
Multiple lines of evidence from molecular studies indicate that individual taste qualities are encoded by distinct taste receptor cells. In contrast, many physiological studies have found that aExpand
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Glucagon‐like peptide‐1 is specifically involved in sweet taste transmission
Five fundamental taste qualities (sweet, bitter, salty, sour, umami) are sensed by dedicated taste cells (TCs) that relay quality information to gustatory nerve fibers. In peripheral taste signalingExpand
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Umami taste in mice uses multiple receptors and transduction pathways
Non‐technical summary  The distinctive umami taste elicited by l‐glutamate and some other amino acids is thought to be initiated by G‐protein‐coupled receptors, such as heteromers of taste receptorExpand
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