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Identification and characterization of receptors for granulocyte colony-stimulating factor on human placenta and trophoblastic cells.
Since radioiodination of human granulocyte colony-stimulating factor (G-CSF) is difficult, we synthesized a mutein of human G-CSF that retains full biological activity and receptor-binding capacityExpand
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Elevated levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) activities in the sera and milk of cows with naturally occurring coliform mastitis.
The presence of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) activities was determined in milk and serum of cows with naturally occurring coliform mastitis (CFM). TNF-alpha wasExpand
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Activity of interleukin 6 in the differentiation of monocytes to macrophages and dendritic cells
Peripheral blood monocytes are common precursor cells of dendritic cells (DCs) and macrophages. We have searched for factors with the potential to regulate the differentiation of monocytes to DCs andExpand
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Leukemia inhibitory factor, LIF receptor, and gp130 in the mouse uterus during early pregnancy
  • Z. Yang, S. Le, +4 authors M. Harper
  • Biology, Medicine
  • Molecular reproduction and development
  • 1 December 1995
Leukemia inhibitory factor (LIF) has been shown to play an important role in the implantation of mouse blastocysts. The present study was designed to investigate the changes of LIF protein, LIFExpand
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Nitric oxide blocks the cell cycle of mouse macrophage‐like cells in the early G2+M phase
The effects of nitric oxide produced by macrophage‐like cells (Mml) on the cell cycle were investigated. Mml cells lost proliferative activity in the presence of interleukin‐6 (IL‐6) and aExpand
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Induction of acute phase protein by recombinant human interleukin-6 (IL-6) in calves.
Interleukin-6 (IL-6) is a major inducer of acute phase proteins in human and murine species. However, the effects of IL-6 have not yet been investigated in cattle. Following continuous infusion ofExpand
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Both D factor/LIF and IL‐6 inhibit the differentation of mouse teratocarcinoma F9 cells
Differentation‐stimulating factor (D factor)/leukemia inhibitory factor (LIF) and IL‐6 are reported to be cytokines having multifaced functions including the induction of differentation in mouseExpand
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Characterization of soluble gp130 released by melanoma cell lines: A polyvalent antagonist of cytokines from the interleukin 6 family.
gp130 acts as a common transducing signal chain for all receptors belonging to the interleukin (IL)-6 receptor family. The IL-6-related cytokines [IL-6, IL-11, oncostatin M (OSM), leukemia inhibitoryExpand
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Inhibitory mechanisms of antibody production by nitrogen oxides released from activated macrophages during the immune response: Relationship to energy consumption
We investigated the relationship between the sensitivity of mouse splenocytes in immune response to nitrogen oxides and energy consumption rate of the cells. Macrophage‐like cells (Mm 1) pretreatedExpand
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Down-regulation of interleukin 6 receptors of mouse myelomonocytic leukemic cells by leukemia inhibitory factor.
We examined the effect of leukemia inhibitory factor (LIF) on the expression of interleukin 6 receptors (IL-6R) on mouse myelomonocytic leukemic M1 cells. Binding studies using 125I-labeled human andExpand
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