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Analysis of hepatic genes involved in the metabolism of fatty acids and iron in nonalcoholic fatty liver disease
- H. Mitsuyoshi, K. Yasui, +6 authors T. Yoshikawa
- Biology, Medicine
- Hepatology research : the official journal of the…
- 1 April 2009
Aims: Hepatic steatosis and iron cause oxidative stress, thereby progressing steatosis to steatohepatitis. We quantified the expression of genes involved in the metabolism of fatty acids and iron in… Expand
SOX2 identified as a target gene for the amplification at 3q26 that is frequently detected in esophageal squamous cell carcinoma.
- Y. Gen, K. Yasui, +11 authors T. Yoshikawa
- Biology, Medicine
- Cancer genetics and cytogenetics
- 15 October 2010
SOX2 is a transcription factor with a high-mobility group DNA-binding domain that functions as a master regulator during embryogenesis and organogenesis. We investigated DNA copy number aberrations… Expand
Alteration in Copy Numbers of Genes as a Mechanism for Acquired Drug Resistance
- K. Yasui, S. Mihara, +9 authors J. Inazawa
- Biology, Medicine
- Cancer Research
- 15 February 2004
Chemoresistance is a major obstacle for successful treatment of cancer. To identify regions of the genome associated with acquired resistance to therapeutic drugs, we conducted molecular cytogenetic… Expand
TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas
- K. Yasui, S. Arii, +5 authors J. Inazawa
- Biology, Medicine
- Hepatology
- 1 June 2002
We carried out molecular cytogenetic characterization of 11 cell lines derived from hepatocellular carcinomas (HCCs) and 51 primary HCCs. Comparative genomic hybridization (CGH) revealed frequent… Expand
Amplification and overexpression of SKP2 are associated with metastasis of non-small-cell lung cancers to lymph nodes.
- S. Yokoi, K. Yasui, M. Mori, T. Iizasa, T. Fujisawa, J. Inazawa
- Biology, Medicine
- The American journal of pathology
- 1 July 2004
SKP2, an F-box protein constituting the substrate recognition subunit of the SCF(SKP2) ubiquitin ligase complex, is implicated in ubiquitin-mediated degradation of the cyclin-dependent kinase… Expand
SOX2 promotes tumor growth of esophageal squamous cell carcinoma through the AKT/mammalian target of rapamycin complex 1 signaling pathway
- Y. Gen, K. Yasui, Taichiro Nishikawa, T. Yoshikawa
- Biology, Medicine
- Cancer science
- 1 July 2013
The transcription factor SOX2 is essential for the maintenance of embryonic stem cells and normal development of the esophagus. Our previous study revealed that the SOX2 gene is an amplification… Expand
ERK5 is a target for gene amplification at 17p11 and promotes cell growth in hepatocellular carcinoma by regulating mitotic entry
- K. Zen, K. Yasui, +13 authors T. Yoshikawa
- Biology, Medicine
- Genes, chromosomes & cancer
- 1 February 2009
Using high‐density oligonucleotide microarrays, we investigated DNA copy‐number aberrations in cell lines derived from hepatocellular carcinomas (HCCs) and detected a novel amplification at 17p11. To… Expand
Activation of B‐Myb by E2F1 in hepatocellular carcinoma
- Tomoaki Nakajima, K. Yasui, +9 authors T. Okanoue
- Biology, Medicine
- Hepatology research : the official journal of the…
- 1 September 2008
Aim: Deregulation of E2F1 transcriptional activity is observed in a variety of cancers, including hepatocellular carcinoma (HCC). The aim of the present study is to identify transcriptional target… Expand
TERC identified as a probable target within the 3q26 amplicon that is detected frequently in non-small cell lung cancers.
- S. Yokoi, K. Yasui, T. Iizasa, I. Imoto, T. Fujisawa, J. Inazawa
- Biology, Medicine
- Clinical cancer research : an official journal of…
- 15 October 2003
PURPOSE
Cell lines derived from non-small cell lung cancers (NSCLCs) revealed frequent high-level gains of chromosomal DNA at 3q23-q29 when examined by comparative genomic hybridization (CGH). Within… Expand
PTK2 and EIF3S3 genes may be amplification targets at 8q23‐q24 and are associated with large hepatocellular carcinomas
- H. Okamoto, K. Yasui, C. Zhao, S. Arii, J. Inazawa
- Biology, Medicine
- Hepatology
- 1 November 2003
We investigated 39 primary hepatocellular carcinomas (HCCs) for aberrations in DNA copy number, using comparative genomic hybridization (CGH). Gain of DNA at 8q was common in these tumors; high‐level… Expand