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A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes
The results indicate that mev-1 governs the rate of ageing by modulating the cellular response to oxidative stress, which may cause an indirect increase in superoxide levels, which in turn leads to oxygen hypersensitivity and premature ageing. Expand
A Defect in the Cytochrome b Large Subunit in Complex II Causes Both Superoxide Anion Overproduction and Abnormal Energy Metabolism in Caenorhabditis elegans *
Important biochemical changes in mev-1 animals are reported that serve to explain their abnormalities under normoxic conditions: an overproduction of superoxide anion from mitochondria; and a reciprocal reduction in glutathione content even under atmospheric oxygen. Expand
Polyhydroxylated alkaloids isolated from mulberry trees (Morusalba L.) and silkworms (Bombyx mori L.).
New polyhydroxylated alkaloids from the root bark of Morus alba L., and 4-O-alpha-D-galactopyranosyl-calystegine B(2) and 3 beta,6 beta-dihydroxynortropane from the fruits were isolated by column chromatography using a variety of ion-exchange resins, suggesting that the silkworm has enzymes specially adapted to enable it to feed on mulberry leaves. Expand
Coenzyme Q10 can prolong C. elegans lifespan by lowering oxidative stress
Data suggest that exogenously supplied CoQ(10) can play a significant anti-aging function and may do so either by acting as an antioxidant to dismutate the free radical superoxide anion or by reducing the uncoupling of reactions during election transport that could otherwise result in superoxideAnion production. Expand
A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis.
The notion that mitochondrially generated oxidative stress can contribute to nuclear DNA damage, mutagenesis, and ultimately, tumorigenesis is underscored. Expand
In vitro inhibition and intracellular enhancement of lysosomal alpha-galactosidase A activity in Fabry lymphoblasts by 1-deoxygalactonojirimycin and its derivatives.
The results suggest that more potent inhibitors act as more effective specific chemical chaperones for the mutant enzyme, and the potent competitive inhibitors of alpha-Gal A are effective specificchemical chaperone for Fabry disease. Expand
Mutant alpha-galactosidase A enzymes identified in Fabry disease patients with residual enzyme activity: biochemical characterization and restoration of normal intracellular processing by
Addition of DGJ to the culture medium of COS-7 cells transfected with a large set of missense mutant alpha-Gal A cDNAs effectively increased both enzyme activity and protein yield, indicating that a large proportion of mutant enzymes in patients with residual enzyme activity are kinetically active. Expand
Antidepressant-like action of nicotine in forced swimming test and brain serotonin in mice
Findings suggest that the involvement of nicotinic and serotonergic systems in the antidepressant-like effects of nicotine are involved. Expand
Adaptive responses to oxidative damage in three mutants of Caenorhabditis elegans (age-1, mev-1 and daf-16) that affect life span
DAF-16, a forkhead/winged-helix transcription factor, whose expression is suppressed by AGE-1, phosphoinositide 3-kinase (PI3-kinases), regulates anti-oxidant genes as well as energy metabolism under atmospheric conditions, suggests that DAF-16 plays a role in the adaptive response against oxidative stress under hyperoxia. Expand
Age-related changes of mitochondrial structure and function in Caenorhabditis elegans
A number of observations have been made to examine the role that mitochrondrial energetics and superoxide anion production play in the aging of wild-type Caenorhabditis elegans. UltrastructuralExpand