• Publications
  • Influence
A prospective study of indexes predicting the outcome of trials of weaning from mechanical ventilation.
  • K. Yang, M. Tobin
  • Medicine
  • The New England journal of medicine
  • 1 February 1992
BACKGROUND The traditional predictors of the outcome of weaning from mechanical ventilation--minute ventilation (VE) and maximal inspiratory pressure (Plmax)--are frequently inaccurate. We developedExpand
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Activation of gene expression in human neutrophils by high mobility group box 1 protein.
High mobility group box 1 (HMGB1) protein, a DNA binding protein that stabilizes nucleosomes and facilitates transcription, was recently identified as a late mediator of endotoxin lethality. HighExpand
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IV delivery of induced pluripotent stem cells attenuates endotoxin-induced acute lung injury in mice.
BACKGROUND Induced pluripotent stem (iPS) cells are novel stem cell populations, but the role of iPS cells in acute lung injury (ALI) is not currently known. We investigated the effect of iPS cellsExpand
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Early alterations in neutrophil activation are associated with outcome in acute lung injury.
Persistent elevations of proinflammatory cytokines in the lungs are associated with increased mortality from acute lung injury (ALI), suggesting that the degree of pulmonary inflammation is anExpand
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Expression of multiple isoenzymes of protein kinase C in airway smooth muscle.
Protein kinase C (PKC) has been implicated in the control of airway smooth muscle (ASM) tone, and abnormalities in PKC-dependent signaling may be associated with asthma. PKC exists in differentExpand
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Decoy receptor 3 levels in peripheral blood predict outcomes of acute respiratory distress syndrome.
  • C. Chen, K. Yang, +7 authors T. Chou
  • Medicine
  • American journal of respiratory and critical care…
  • 15 October 2009
RATIONALE Acute respiratory distress syndrome (ARDS), a serious inflammatory reaction to acute lung injury, is associated with high mortality rates. Decoy receptor (DcR) 3 is a soluble protein withExpand
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Increased cortical nuclear factor-κB (NF-κB) DNA binding activity after traumatic brain injury in rats
Nuclear factor-kappa B (NF-kappa B) DNA binding factor is an inducible transcription factor that responds to various cellular signals. Levels of cortical NF-kappa B DNA binding activity were measuredExpand
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Mesenchymal stem cells enhance lung cancer initiation through activation of IL-6/JAK2/STAT3 pathway.
BACKGROUND The role of mesenchymal stem cells (MSCs) and IL-6 in lung cancer has not been well-addressed. We aimed to determine if MSCs can enhance the ability of tumor initiation of lung cancerExpand
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Involvement of phosphatidylinositol 3-kinase γ in neutrophil apoptosis
Abstract Although phosphoinositide 3-kinases (PI3-K) are known to participate in anti-apoptotic pathways, their importance in modulating neutrophil apoptosis in vivo has not been examined. In theseExpand
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Tracheal stenosis after a brief intubation.
  • K. Yang
  • Medicine
  • Anesthesia and analgesia
  • 1 March 1995
A lthough the incidence of airway complications is correlated with the duration of endotracheal intubation, long-term complications are rare when intubation is less than a week. A patient whoExpand
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