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- Publications
- Influence
“Pseudo” γ-Butyrolactone Receptors Respond to Antibiotic Signals to Coordinate Antibiotic Biosynthesis*
In actinomycetes, the onset of secondary metabolite biosynthesis is often triggered by the quorum-sensing signal γ-butyrolactones (GBLs) via specific binding to their cognate receptors. However, the… Expand
Autoregulation of antibiotic biosynthesis by binding of the end product to an atypical response regulator
- L. Wang, X. Tian, +5 authors H. Tan
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 26 May 2009
In bacteria, many “atypical” response regulators (ARRs) lack the conserved residues important for phosphorylation by which typical response regulators switch their output response, suggesting the… Expand
Characterization of the Protocatechuic Acid Catabolic Gene Cluster from Streptomyces sp. Strain 2065
- S. Iwagami, K. Yang, J. Davies
- Medicine, Biology
- Applied and Environmental Microbiology
- 1 April 2000
ABSTRACT Protocatechuate 3,4-dioxygenase (EC 1.13.11.3 ) catalyzes the ring cleavage step in the catabolism of aromatic compounds through the protocatechuate branch of the β-ketoadipate pathway. A… Expand
A novel role of ‘pseudo’γ‐butyrolactone receptors in controlling γ‐butyrolactone biosynthesis in Streptomyces
In streptomycetes, a quorum‐sensing mechanism mediated by γ‐butyrolactones (GBLs) and their cognate receptors was known to trigger secondary metabolism and morphological differentiation. However,… Expand
The dynamic structure of jadomycin B and the amino acid incorporation step of its biosynthesis.
- U. Rix, J. Zheng, Lily L. Remsing Rix, Lisa Greenwell, K. Yang, J. Rohr
- Chemistry, Medicine
- Journal of the American Chemical Society
- 20 March 2004
Jadomycin B, an antifungal antibiotic with a unique 8H-benz[b]oxazolo[3,2-f]phenanthridine pentacyclic skeleton produced by the bacterium Streptomyces venezuelae ISP 5230, exists in a dynamic… Expand
Functional Characterization of the jadI Gene As a Cyclase Forming Angucyclinones
- K. Kulowski, E. Wendt-Pienkowski, Lei Han, K. Yang, and Leo C. Vining, C. Hutchinson
- Chemistry
- 17 February 1999
A gene designated jadI from the jadomycin B producer Streptomyces venezuelae has homology to the tetracenomycin pathway tcmI gene and encodes a putative cyclase for angucyclinone biosynthesis.… Expand
ScbR- and ScbR2-mediated signal transduction networks coordinate complex physiological responses in Streptomyces coelicolor
In model organism Streptomyces coelicolor, γ-butyrolactones (GBLs) and antibiotics were recognized as signalling molecules playing fundamental roles in intra- and interspecies communications. To… Expand
Inactivation of Chloramphenicol by O-Phosphorylation
- R. H. Mosher, D. Camp, K. Yang, M. Brown, W. Shaw, L. Vining
- Biology, Medicine
- The Journal of Biological Chemistry
- 10 November 1995
Plasmid pJV4, containing a 2.4-kilobase pair insert of genomic DNA from the chloramphenicol (Cm) producer Streptomyces venezuelae ISP5230, confers resistance when introduced by transformation into… Expand
A Blue Native-PAGE analysis of membrane protein complexes in Clostridium thermocellum
- Yanfeng Peng, Yuanming Luo, +4 authors K. Yang
- Biology, Medicine
- BMC Microbiology
- 26 January 2011
BackgroundClostridium thermocellum is a Gram-positive thermophilic anaerobic bacterium with the unusual capacity to convert cellulosic biomass into ethanol and hydrogen. Identification and… Expand
Functional Analyses of Oxygenases in Jadomycin Biosynthesis and Identification of JadH as a Bifunctional Oxygenase/Dehydrase*
- Yi-hua Chen, C. Wang, +5 authors K. Yang
- Medicine, Biology
- Journal of Biological Chemistry
- 10 June 2005
A novel angucycline metabolite, 2,3-dehydro-UWM6, was identified in a jadH mutant of Streptomyces venezuelae ISP5230. Both UWM6 and 2,3-dehydro-UWM6 could be converted to jadomycin A or B by a… Expand