• Publications
  • Influence
“Pseudo” γ-Butyrolactone Receptors Respond to Antibiotic Signals to Coordinate Antibiotic Biosynthesis*
  • G. Xu, J. Wang, +5 authors H. Tan
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 18 June 2010
In actinomycetes, the onset of secondary metabolite biosynthesis is often triggered by the quorum-sensing signal γ-butyrolactones (GBLs) via specific binding to their cognate receptors. However, theExpand
  • 102
  • 12
Autoregulation of antibiotic biosynthesis by binding of the end product to an atypical response regulator
  • L. Wang, X. Tian, +5 authors H. Tan
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 26 May 2009
In bacteria, many “atypical” response regulators (ARRs) lack the conserved residues important for phosphorylation by which typical response regulators switch their output response, suggesting theExpand
  • 105
  • 11
Characterization of the Protocatechuic Acid Catabolic Gene Cluster from Streptomyces sp. Strain 2065
ABSTRACT Protocatechuate 3,4-dioxygenase (EC 1.13.11.3 ) catalyzes the ring cleavage step in the catabolism of aromatic compounds through the protocatechuate branch of the β-ketoadipate pathway. AExpand
  • 88
  • 7
  • PDF
A novel role of ‘pseudo’γ‐butyrolactone receptors in controlling γ‐butyrolactone biosynthesis in Streptomyces
In streptomycetes, a quorum‐sensing mechanism mediated by γ‐butyrolactones (GBLs) and their cognate receptors was known to trigger secondary metabolism and morphological differentiation. However,Expand
  • 54
  • 5
  • PDF
The dynamic structure of jadomycin B and the amino acid incorporation step of its biosynthesis.
Jadomycin B, an antifungal antibiotic with a unique 8H-benz[b]oxazolo[3,2-f]phenanthridine pentacyclic skeleton produced by the bacterium Streptomyces venezuelae ISP 5230, exists in a dynamicExpand
  • 66
  • 4
Functional Characterization of the jadI Gene As a Cyclase Forming Angucyclinones
A gene designated jadI from the jadomycin B producer Streptomyces venezuelae has homology to the tetracenomycin pathway tcmI gene and encodes a putative cyclase for angucyclinone biosynthesis.Expand
  • 62
  • 4
ScbR- and ScbR2-mediated signal transduction networks coordinate complex physiological responses in Streptomyces coelicolor
In model organism Streptomyces coelicolor, γ-butyrolactones (GBLs) and antibiotics were recognized as signalling molecules playing fundamental roles in intra- and interspecies communications. ToExpand
  • 27
  • 4
Inactivation of Chloramphenicol by O-Phosphorylation
Plasmid pJV4, containing a 2.4-kilobase pair insert of genomic DNA from the chloramphenicol (Cm) producer Streptomyces venezuelae ISP5230, confers resistance when introduced by transformation intoExpand
  • 47
  • 3
A Blue Native-PAGE analysis of membrane protein complexes in Clostridium thermocellum
BackgroundClostridium thermocellum is a Gram-positive thermophilic anaerobic bacterium with the unusual capacity to convert cellulosic biomass into ethanol and hydrogen. Identification andExpand
  • 13
  • 3
  • PDF
Functional Analyses of Oxygenases in Jadomycin Biosynthesis and Identification of JadH as a Bifunctional Oxygenase/Dehydrase*
A novel angucycline metabolite, 2,3-dehydro-UWM6, was identified in a jadH mutant of Streptomyces venezuelae ISP5230. Both UWM6 and 2,3-dehydro-UWM6 could be converted to jadomycin A or B by aExpand
  • 62
  • 2
  • PDF