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A Novel Mechanism Involving Four-and-a-half LIM Domain Protein-1 and Extracellular Signal-regulated Kinase-2 Regulates Titin Phosphorylation and Mechanics*
Background: Titin is critical for cardiac muscle function; however, limited knowledge exists of mechanisms important for its regulation. Results: A four-and-a-half LIM domain protein-1/extracellularExpand
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Short- and long-term effects of (-)-epicatechin on myocardial ischemia-reperfusion injury.
Epidemiological studies have shown a correlation between flavonoid-rich diets and improved cardiovascular prognosis. Cocoa contains large amounts of flavonoids, in particular flavanols (mostlyExpand
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Regulation of cardiac fibroblast collagen synthesis by adenosine: roles for Epac and PI3K.
Rat cardiac fibroblasts (CF) express multiple adenosine (ADO) receptors. Pharmacological evidence suggests that activation of A(2) receptors may inhibit collagen synthesis via adenylylExpand
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Effects of (-)-epicatechin on myocardial infarct size and left ventricular remodeling after permanent coronary occlusion.
OBJECTIVES We examined the effects of the flavanol (-)-epicatechin on short- and long-term infarct size and left ventricular (LV) structure and function after permanent coronary occlusion (PCO) andExpand
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Intravenous (-)-epicatechin reduces myocardial ischemic injury by protecting mitochondrial function.
BACKGROUND Targeting the mitochondria during ischemia/reperfusion (IR) can confer cardioprotection leading to improved clinical outcomes. The cardioprotective potential of (-)-epicatechin (EPI)Expand
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Changes in regional myocardial volume during the cardiac cycle: implications for transmural blood flow and cardiac structure.
Although previous studies report a reduction in myocardial volume during systole, myocardial volume changes during the cardiac cycle have not been quantitatively analyzed with high spatiotemporalExpand
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Co-administration of the flavanol (-)-epicatechin with doxycycline synergistically reduces infarct size in a model of ischemia reperfusion injury by inhibition of mitochondrial swelling.
(-)-Epicatechin (EPI) is cardioprotective in the setting of ischemia/reperfusion (IR) injury and doxycycline (DOX) is known to preserve cardiac structure/function after myocardial infarction (MI).Expand
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Ventricular pacing-induced loss of contractile function and development of epicardial inflammation.
Perturbations in the normal sequence of ventricular activation can create regions of early and late activation, leading to dysynchronous contraction and areas of dyskinesis. Dyskinesis occurs acrossExpand
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Cell adhesion molecule mediation of myocardial inflammatory responses associated with ventricular pacing.
Poorly synchronized activation of the ventricles can lead to impairment of normal cardiac structure/function. We reported previously that short term (4 h) left ventricular (LV) pacing-inducedExpand
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Effects of Epicatechin on AMPK, GLUT4 and TNF-α in the onset of Type 2 Diabetes
An abnormally high level of blood glucose is the key characteristic of type 2 diabetes (T2D). Several studies have established that this results from decreased translocation of glucose transporters...
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