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Identification of cells initiating human melanomas
Tumour-initiating cells capable of self-renewal and differentiation, which are responsible for tumour growth, have been identified in human haematological malignancies and solid cancers. If suchExpand
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The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model.
T cell Ig mucin 1 (TIM-1) plays an important role in regulating immune responses in autoimmune and asthma models, and it is expressed on both Th1 and Th2 cells. Using an antagonistic TIM-1-specificExpand
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A Novel Alloantigen-Specific CD8+PD1+ Regulatory T Cell Induced by ICOS-B7h Blockade In Vivo1
Delayed ICOS-B7h signal blockade promotes significant prolongation of cardiac allograft survival in wild-type but not in CD8-deficient C57BL/6 recipients of fully MHC-mismatched BALB/c heartExpand
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PDL1 Is Required for Peripheral Transplantation Tolerance and Protection from Chronic Allograft Rejection1
The PD-1:PDL pathway plays an important role in regulating alloimmune responses but its role in transplantation tolerance is unknown. We investigated the role of PD-1:PDL costimulatory pathway inExpand
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Intramedullary spinal cord germinoma. Case report and review of the literature.
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Recurrent ventricular tachyarrhythmias associated with QT prolongation following hydrofluoric acid burns.
BACKGROUND Some hydrofluoric acid burns appear initially as only a slight wound, but patients may show dramatic changes within several hours. The extent of such burns are directly related to theExpand
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In Vivo Function of Immune Inhibitory Molecule B7‐H4 in Alloimmune Responses
B7 ligands deliver both costimulatory and coinhibitory signals to the CD28 family of receptors on T lymphocytes, the balance between which determines the ultimate immune response. Although B7‐H4, aExpand
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Differential Requirement of CD27 Costimulatory Signaling for Naïve Versus Alloantigen‐Primed Effector/Memory CD8+ T Cells
CD8+ memory T cells endanger allograft survival by causing acute and chronic rejection and prevent tolerance induction. We explored the role of CD27:CD70 T‐cell costimulatory pathway in alloreactiveExpand
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A novel in vivo regulatory role of P-glycoprotein in alloimmunity.
P-glycoprotein (P-gp) is required for adaptive immunity through defined functions in T cell activation and antigen presenting cell (APC) maturation. The potential role of P-gp as an in vivo regulatorExpand
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