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Decrease in the prevalence of IL-4-producing CD4+ T cells in patients with advanced stage of primary biliary cirrhosis
TLDR
The results suggest that, mainly as a result of the decline of Th2, a predominance of Th1 may exist in advanced stage PBC.
Contrasuppression. A novel immunoregulatory activity
TLDR
An interaction between two T cells subsets that results in interference with the expression of Ly-1-, 2+ (Ly-2) T cell- mediated suppression is described and the potential importance of contrasuppression activity in the regulation of suppressor T cell activity in allowing immunologic memory to be expressed and in permitting microenvironmental immune regulation is discussed.
Molecular composition of an antigen-specific, Ly-1 T suppressor inducer factor. One molecule binds antigen and is I-J-; another is I-J+, does not bind antigen, and imparts an Igh-variable
TLDR
Any of the three heterologous erythrocytes (antigens) studied can be used for immunization to produce the I-J+ nonantigen-binding factor, and the antigen combining site of the factor is irrelevant to the factor's Igh-V restriction but crucial for its specificity.
T-2 toxin induces thymic apoptosis in vivo in mice.
TLDR
T-2 toxin-induced thymic atrophy is associated with cell death through a mechanism of apoptosis, and neither endogenous glucocorticoid nor TNF-alpha appeared to be involved in the apoptotic process.
Genetic alterations of the putative envelope proteins encoding region of the hepatitis C virus in the progression to relapsed phase from acute hepatitis: Humoral immune response to hypervariable
TLDR
This analysis found that a Leu (position 405) in HVRI substituted to Pro, and that 4 additional substitutions could be detected in gp70 during the relapsed phase, and demonstrated the existence of important a mi no‐acid residue positions which are recognized by the anti‐HVRI antibody produced in patient M using introduction point mutations within HV RI.
Significance of soluble TNF receptor-I in acute-type fulminant hepatitis
TLDR
It is suggested that monitoring the soluble TNF receptor-I level may help to assess the prognosis of acute-type fulminant hepatitis and that TNF might be associated with massive hepatic necrosis.
Influence of TNF gene polymorphism in patients with acute and fulminant hepatitis
TLDR
The data suggest that the genomic background may be associated with the prognosis of acute liver failure, andFH patients with a poor prognosis had higher frequencies of positions −1031C and −863A in the TNF-α promoter region, and higher frequency of the B2 allele of the T NF-β gene.
Analysis of adhesion molecules in patients with idiopathic portal hypertension
TLDR
A large number of patients with idiopathic portal hypertension are diagnosed with atypical central giant cell granuloma, which is a leading cause of death in patients with IPH.
Induction of autologous tumor‐specific cytotoxic T cells in patients with liver cancer. Characterizations and clinical utilization
TLDR
Autologous‐tumor‐specific cytotoxic T cells obtained from cancer patients and injected into patients having either non‐resected tumors or recurrent tumors in the liver demonstrated that these in vitro‐stimulated cells were able to kill autologous tumor cells but not allogeneic tumors.
Differential activation of cytotoxic and suppressor T cells against syngeneic tumors in the mouse.
TLDR
The results that cytotoxic and suppressor T cells are activated under different conditions, and that the antigenic determinants recognizable by these two cell types are not the same, are confirmed.
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