• Publications
  • Influence
The N-terminal carbohydrate recognition domain of galectin-8 recognizes specific glycosphingolipids with high affinity.
TLDR
This is the first demonstration that galectin-8 binds to specific sulfated or sialylated glycosphingolipids with high affinity, indicating that this Gln47 plays important roles for binding to Neu5Acalpha2-->3Gal or SO3--->3Gal residues. Expand
Fractionation of L-fucose-containing oligosaccharides on immobilized Aleuria aurantia lectin.
TLDR
The carbohydrate-binding specificity of Aleuria aurantia lectin was investigated by analyzing the behavior of a variety of fucose-containing oligosaccharides on an A. aurantial lectin-Sepharose column and results indicated that A. Aurantia Lectin- Sepharose is useful for the group separation of mixtures of complex-type asparagine-linked sugar chains. Expand
Galectin-8-N-domain Recognition Mechanism for Sialylated and Sulfated Glycans*
TLDR
This study elucidated the crystal structures of the human galectin-8-N-domain (-8N) in the absence or presence of 4 ligands and found that Arg45, Gln47, Arg59, and the long loop region between the S3 and S4 β-strands are unique to galectIn-8N. Expand
Structural studies of two ovalbumin glycopeptides in relation to the endo-beta-N-acetylglucosaminidase specificity.
TLDR
The presence of the unsubstituted alpha-mannosyl residue linked at the C-3 position of the terminal mannose of Manbeta1 leads to 4 GlcNAcAsn core must be essential for the action of the enzyme. Expand
Galectin-4 Binds to Sulfated Glycosphingolipids and Carcinoembryonic Antigen in Patches on the Cell Surface of Human Colon Adenocarcinoma Cells*
TLDR
It is found that galectin-4 binds to glycosphingolipids carrying 3-O-sulfated Gal residues, such as SB1a, SM3, SM4s, SB2, SM2a, and GM1, but not to Glycobiology residues with 3- O-sialylated Gal, using both an enzyme-linked immunosorbent assay and a surface plasmon resonance assay. Expand
Structural Basis for Recognition of High Mannose Type Glycoproteins by Mammalian Transport Lectin VIP36*
TLDR
The crystal structure of VIP36 exoplasmic/luminal domain comprising a carbohydrate recognition domain and a stalk domain reveals that a coordinated Ca2+ ion orients the side chains of Asp131, Asn166, and His190 for carbohydrate binding, explaining the Ca2-dependent carbohydrate binding of this protein. Expand
Structural studies of the carbohydrate moieties of carcinoembryonic antigens.
TLDR
Three samples of carcinoembryonic antigens were purified from liver metastases of primary colon cancer and the structures of oligosaccharides, thus obtained, was studied in combination with methylation analysis and several limited exoglycosidase digestions. Expand
alpha1,2-Fucosylated and beta-N-acetylgalactosaminylated prostate-specific antigen as an efficient marker of prostatic cancer.
TLDR
The results indicated that both TJA-II-bound PSA content and T JA-II binding ratios could be used to discriminate between PC and BPH with more than 95% probability, and TJA -II- bound PSA can be regarded as a potential marker of PC. Expand
...
1
2
3
4
5
...