• Publications
  • Influence
Paraoxonase polymorphism (Gln192-Arg) is associated with coronary heart disease in Japanese noninsulin-dependent diabetes mellitus.
Serum paraoxonase/arylesterase (PONA) is associated with high-density lipoprotein and may prevent oxidation of low-density lipoprotein by hydrolyzing lipid peroxides. A recent report suggested anExpand
  • 159
  • 7
Comparison of the effects of glucagon-like peptide-1-(1-37) and -(7-37) and glucagon on islet hormone release from isolated perfused canine and rat pancreases.
Recently, it has been demonstrated that glucagon-like peptide-1 (GLP-1)-(7-37) possesses a potent insulinotropic activity. In this paper, we compared the effects of GLP-1-(1-37) and -(7-37) andExpand
  • 93
  • 5
Prevalence and clinical characterization of Japanese diabetes mellitus with an A-to-G mutation at nucleotide 3243 of the mitochondrial tRNA(Leu(UUR)) gene.
An A-to-G mutation at nucleotide position 3243 of the mitochondrial genome has been associated with insulin-dependent diabetes mellitus (IDDM) and with noninsulin-dependent diabetes mellitus (NIDDM)Expand
  • 54
  • 5
Evidence that glucagon stimulates insulin secretion through its own receptor in rats
SummarySince glucagon-like peptide-1 (7–36) amide (7–37) (GLP-1) has been found to be a potent insulinotropic hormone, it has been postulated that glucagon stimulates insulin secretion from isletExpand
  • 77
  • 3
  • PDF
Radioimmunoassay of human proinsulin C-peptide using synthetic human connecting peptide.
Radioimmunoassay of human C-peptide was established using antiserum to synthetic human connecting peptide and synthetic tyrosylated human connecting peptide. Synthetic human connecting peptide andExpand
  • 133
  • 2
In vitro antimycobacterial activities of newly synthesized benzoxazinorifamycins.
Newly synthesized rifamycin derivatives, KRM-1648, KRM-1657, KRM-1668, KRM-1686, and KRM-1687, having the chemical structures of 3'-hydroxy-5'-(4-alkylpiperazinyl)-benzoxazinorifamycins (alkylExpand
  • 110
  • 2
  • PDF
Comparison of the effects of various C-terminal and N-terminal fragment peptides of glucagon-like peptide-1 on insulin and glucagon release from the isolated perfused rat pancreas.
Truncated glucagon-like peptide-1 (GLP-1) possesses a potent stimulatory activity for insulin secretion and a slight inhibiting activity for glucagon secretion. The aim of this paper is to examineExpand
  • 114
  • 2
Ocular vascular endothelial growth factor levels in diabetic rats are elevated before observable retinal proliferative changes
Summary Vascular endothelial growth factor (VEGF) is a potent angiogenic factor. VEGF levels in ocular tissue of 6-, 12-, 18- and 28-week-old Goto-Kakizaki (GK) rats, a well-known model ofExpand
  • 141
  • 2
Counterproductive effects of sodium bicarbonate in diabetic ketoacidosis.
Although a growing body of evidence supports that alkali therapy in diabetic ketoacidosis (DKA) might be counterproductive, our knowledge about the consequences of this treatment on ketone metabolismExpand
  • 101
  • 2
Usefulness of palatinose as a caloric sweetener for diabetic patients.
  • 77
  • 2