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Effect of chitosan film containing basic fibroblast growth factor on wound healing in genetically diabetic mice.
It is suggested that chitosan itself facilitates wound repair and that bFGF incorporated into chitOSan film is a stabile delivery vehicle for accelerating wound healing. Expand
Synthesis of antibiotic-loaded hydroxyapatite beads and in vitro drug release testing.
To protect relatively unstable drugs from humidity and avoid contamination of drug-incorporated HAP beads an apparatus was designed with which the beads could be enclosed in vials in vacuo and under aseptic conditions on a bench-scale basis. Expand
Design, synthesis and evaluation of caffeic acid phenethyl ester-based inhibitors targeting a selectivity pocket in the active site of human aldo-keto reductase 1B10.
It is found that, among honeybee propolis products, caffeic acid phenethyl ester (CAPE) inhibited AKR1B10 (IC(50) = 80 nM) with 7-fold selectivity over AKR2B10 over aldose reductase (AKR 1B1), and the sub-μM concentration of 10c significantly suppressed the farnesal metabolism and cellular proliferation in AKR0-overexpressing cells. Expand
Distribution and serum concentration of sisomicin released from fibrin glue-sealed dacron graft in the rat and human.
Clinical applications and animal experiment results suggest that FG is useful as a carrier of SISO, allowing its controlled release for the prevention of local infection. Expand
Acquisition of doxorubicin resistance facilitates migrating and invasive potentials of gastric cancer MKN45 cells through up-regulating aldo-keto reductase 1B10.
Results suggest that AKR1B10 is a DOX-resistance gene in the gastric cancer cells, and is responsible for elevating the migrating and invasive potentials of the cells through induction of MMP2. Expand
Pain relief of oral ulcer by dibucaine-film
A water-soluble three-layered oral mucosa-adhesive film made from hydroxypropyl cellulose containing dibucaine (0.25 mg of drug/cm(2)) was designed for alleviation of severe pain due to oral ulcers,Expand
High-performance liquid chromatographic assay for prostaglandin E1 in various ointment vehicles. Separation and stability testing.
A high-performance liquid chromatographic method for the determination of prostaglandin E1 (PGE1) incorporated in white petrolatum, white ointment, hydrophilic petrolatum and Plastibase was investigated and the drug remained intact for up to 6 months when stored at 5 degrees C. Expand
Simultaneous determinations of cefsulodin and cefotiam in serum and bone marrow blood by high-performance liquid chromatography.
The concentrations of cefsulodin and cefotiam, concurrently administered by the intravenous route to patients subjected to artificial total joint prosthesis, in serum and bone marrow blood collected at 0.5 and 1 hr postinjection were almost equivalent. Expand
Subcutaneous tissue distribution of vancomycin from a fibrin glue/Dacron graft carrier.
The results suggest that this VCM-FG Dacron graft delivery may be useful in preventing local infection by enhancing the delivery of VCM to the local areas of the implanted site in rats. Expand