Fibronectin at a glance
Fibronectin (FN) mediates a wide variety of cellular interactions with the extracellular matrix (ECM) and plays important roles in cell adhesion, migration, growth and differentiation ( [Mosher,…
Taking Cell-Matrix Adhesions to the Third Dimension
- E. Cukierman, R. Pankov, Daron R. Stevens, K. Yamada
- BiologyScience
- 23 November 2001
These distinctive in vivo 3D-matrix adhesions differ in structure, localization, and function from classically described in vitro adhesion, and as such they may be more biologically relevant to living organisms.
Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function.
- V. Artym, Ying Zhang, F. Seillier-Moiseiwitsch, K. Yamada, S. Mueller
- BiologyCancer Research
- 15 March 2006
It is shown that invadopodia have two distinct aspects: structural for organizing the cellular actin cytoskeleton to form membrane protrusions and functional for using proteolytic enzyme(s) for ECM degradation.
One-dimensional topography underlies three-dimensional fibrillar cell migration
- Andrew D. Doyle, Francis W. Wang, Kazue Matsumoto, K. Yamada
- BiologyJournal of Cell Biology
- 23 February 2009
It is proposed that cells migrate rapidly through 3D fibrillar matrices by a 1D migratory mechanism not mimicked by 2D matrices.
Random versus directionally persistent cell migration
- R. Petrie, Andrew D. Doyle, K. Yamada
- BiologyNature reviews. Molecular cell biology
- 1 August 2009
Factors such as the topography of the extracellular matrix, the cellular polarity machinery, receptor signalling, integrin trafficking, Integrin co-receptors and actomyosin contraction converge on regulation of the Rho family of GTPases and the control of lamellipodial protrusions to promote directional migration.
The relationship between force and focal complex development
- C. Galbraith, K. Yamada, M. Sheetz
- BiologyJournal of Cell Biology
- 25 November 2002
It is shown that initial integrin–ECM adhesions become capable of exerting migration force with the recruitment of vinculin, a marker for focal complexes, which are precursors of focal adhesion.
Transmembrane crosstalk between the extracellular matrix and the cytoskeleton
- B. Geiger, A. Bershadsky, R. Pankov, K. Yamada
- BiologyNature reviews. Molecular cell biology
- 1 November 2001
This review describes integrin functions, mechanosensors, molecular switches and signal-transduction pathways activated and integrated by adhesion, with a unifying theme being the importance of local physical forces.
Myosin IIA regulates cell motility and actomyosin–microtubule crosstalk
- S. Even-Ram, Andrew D. Doyle, M. Conti, Kazue Matsumoto, R. Adelstein, K. Yamada
- BiologyNature Cell Biology
- 18 February 2007
It is concluded that myosin IIA negatively regulates cell migration and it is suggested that it maintains a balance between the actomyosin and microtubules systems by regulating microtubule dynamics.
Nonpolarized signaling reveals two distinct modes of 3D cell migration
- R. Petrie, N. Gavara, R. Chadwick, K. Yamada
- BiologyJournal of Cell Biology
- 30 April 2012
The elastic behavior of the 3D extracellular matrix determines the relative polarization of intracellular signaling and whether cells migrate using lamellipodia or lobopodia.
Cell–matrix adhesion
- A. Berrier, K. Yamada
- BiologyJournal of Cellular Physiology
- 1 December 2007
This mini review discusses the roles of matrix properties such as composition, three‐dimensionality, and porosity, the bi‐directional functions of cellular contractility and matrix rigidity, and cell signaling in the formation of cell adhesions, assembly of matrix, migration, and tumorigenesis and speculates on the application of this knowledge to potential future therapeutic approaches.
...
...