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Fibronectin at a glance

Fibronectin (FN) mediates a wide variety of cellular interactions with the extracellular matrix (ECM) and plays important roles in cell adhesion, migration, growth and differentiation ( [Mosher,…
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Taking Cell-Matrix Adhesions to the Third Dimension

These distinctive in vivo 3D-matrix adhesions differ in structure, localization, and function from classically described in vitro adhesion, and as such they may be more biologically relevant to living organisms.
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Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function.

It is shown that invadopodia have two distinct aspects: structural for organizing the cellular actin cytoskeleton to form membrane protrusions and functional for using proteolytic enzyme(s) for ECM degradation.
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One-dimensional topography underlies three-dimensional fibrillar cell migration

It is proposed that cells migrate rapidly through 3D fibrillar matrices by a 1D migratory mechanism not mimicked by 2D matrices.
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Random versus directionally persistent cell migration

Factors such as the topography of the extracellular matrix, the cellular polarity machinery, receptor signalling, integrin trafficking, Integrin co-receptors and actomyosin contraction converge on regulation of the Rho family of GTPases and the control of lamellipodial protrusions to promote directional migration.
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The relationship between force and focal complex development

It is shown that initial integrin–ECM adhesions become capable of exerting migration force with the recruitment of vinculin, a marker for focal complexes, which are precursors of focal adhesion.
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Transmembrane crosstalk between the extracellular matrix and the cytoskeleton

This review describes integrin functions, mechanosensors, molecular switches and signal-transduction pathways activated and integrated by adhesion, with a unifying theme being the importance of local physical forces.
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Myosin IIA regulates cell motility and actomyosin–microtubule crosstalk

It is concluded that myosin IIA negatively regulates cell migration and it is suggested that it maintains a balance between the actomyosin and microtubules systems by regulating microtubule dynamics.
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Nonpolarized signaling reveals two distinct modes of 3D cell migration

The elastic behavior of the 3D extracellular matrix determines the relative polarization of intracellular signaling and whether cells migrate using lamellipodia or lobopodia.
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Cell–matrix adhesion

This mini review discusses the roles of matrix properties such as composition, three‐dimensionality, and porosity, the bi‐directional functions of cellular contractility and matrix rigidity, and cell signaling in the formation of cell adhesions, assembly of matrix, migration, and tumorigenesis and speculates on the application of this knowledge to potential future therapeutic approaches.
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