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Prolonged inhibition of vascular contraction and calcium influx by the novel 1,4-dihydropyridine calcium antagonist cinaldipine (FRC-8653).
- R. Yoshimoto, H. Dohmoto, K. Yamada, A. Goto
- Chemistry, MedicineJapanese journal of pharmacology
It is suggested that prolonged inhibition of calcium influx through L-channels contributes to the long-lasting vasodilative and antihypertensive activity of FRC-8653.
Physiology and pharmacology of endogenous digitalis-like factors.
Adrenocorticotropin-induced hypertension in rats: role of ouabain-like compound.
Measurement of OLC levels after the fractionation of urine by reverse-phase high performance liquid chromatography showed that the major OLC peak in urine from both groups coincided with that of authentic ouabain, suggesting the contribution of O LC to ACTH-induced hypertension in rats.
Putative roles of ouabainlike compound in hypertension: revisited.
The blockade of OLC action may become the basis of novel rational antihypertensive agents and may help to solve the problems still present in the management of hypertensive patients.
Digoxin-like immunoreactivity: is it still worth measuring?
Issues relating to the possible physiological roles of digoxin-like immunoreactivity which may or may not be related to the regulation of sodium pump are critically reviewed in this article.
Effects of intracerebroventricular administration of 6‐hydroxydopamine on ouabain‐like immunoreactivity in plasma and the hypothalamo‐pituitary axis in rats
The results suggest that the production and release of ouabain-like factor are closely associated with the brain, particularly the hypothalamus-pituitary axis, and that noradrenergic or dopaminergic neurons, or both, play a key role in this mechanism.
Role of ouabainlike compound in rats with reduced renal mass-saline hypertension.
- K. Yamada, A. Goto, +4 authors T. Sugimoto
- Chemistry, MedicineThe American journal of physiology
- 1 April 1994
Findings suggest that plasma OLC shows a similar behavior to that of EDLFs or Na(+)-K(+-adenosinetriphosphatase inhibitors reported in previous publications and may play a role in hypertensive mechanisms in rats with RRM and excess Na intake.
Modulation of vascular calcium channel activity in response to acute volume expansion in rats.
The hypothesis that volume expansion per se may cause the alterations of PSC similar to those seen in hypertension is tested and it is suggested that acute volume expansion could induce a similar enhanced vascular Ca2+ channel activity to that seen in pulmonary hypertension in rats.
Participation of Ouabainlike Compound in Reduced Renal Mass–Saline Hypertension
It is suggested that circulating ouabainlike compound may be involved in the pathophysiology in this model of hypertension and partly ameliorates reduced renal mass-saline hypertension.
PLASMA ADENOSINE CONCENTRATIONS ARE ELEVATED IN CONSCIOUS SPONTANEOUSLY HYPERTENSIVE RATS
- K. Yamada, A. Goto, M. Ishii, M. Yoshioka, H. Matsuoka, T. Sugimoto
- Chemistry, MedicineClinical and experimental pharmacology…
- 1 August 1992
1. Plasma levels of adenosine were measured in unrestrained, conscious spontaneously hypertensive rats (SHR) to examine the potential role of adenosine, a naturally occurring substance with profound…