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CD38 is critical for social behaviour by regulating oxytocin secretion
CD38, a transmembrane glycoprotein with ADP-ribosyl cyclase activity, catalyses the formation of Ca2+ signalling molecules, but its role in the neuroendocrine system is unknown. Here we show thatExpand
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Involvement of BDNF receptor TrkB in spatial memory formation.
The N-methyl-D-aspartate (NMDA) receptors are involved in long-term potentiation (LTP), and are phosphorylated by several tyrosine kinases including a Src-family tyrosine kinase Fyn. Brain-derivedExpand
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Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood
Gene-environment interaction may play a role in the etiology of schizophrenia. Transgenic mice expressing dominant-negative DISC1 (DN-DISC1 mice) show some histological and behavioral endophenotypesExpand
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A Role of Fos Expression in the CA3 Region of the Hippocampus in Spatial Memory Formation in Rats
Activity-dependent plastic changes in the strength of synaptic connections are considered to underlie learning and memory. Activation of neurons by a variety of stimuli influences the level ofExpand
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Cognition impairment in the genetic model of aging klotho gene mutant mice: a role of oxidative stress
A new gene, termed klotho, is associated with the suppression of several aging phenotypes. Because high expression of klotho gene was detected in the brain, it would be plausible that klotho gene isExpand
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Brain-derived neurotrophic factor/TrkB signaling in memory processes.
Activity-dependent changes in synaptic strength are considered mechanisms underlying learning and memory. Brain-derived neurotrophic factor (BDNF) plays an important role in activity-dependentExpand
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CREB phosphorylation as a molecular marker of memory processing in the hippocampus for spatial learning
Regulation of gene transcription via the cyclic adenosine 3',5'-monophosphate (cAMP)-mediated second messenger pathway has been implicated in learning and memory. Although the cAMP responseExpand
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Role for brain-derived neurotrophic factor in learning and memory.
In addition to its actions on neuronal survival and differentiation, brain-derived neurotrophic factor (BDNF) has a role in the regulation of synaptic strength. Long-term potentiation, a form ofExpand
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Production and functions of IL-17 in microglia
Interleukin (IL)-17-producing helper T cells may play a pivotal role in the pathogenesis of multiple sclerosis. Here, we examined the effects of IL-17 on microglia, which are known to be criticallyExpand
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Comparison of mesenchymal stem cells from adipose tissue and bone marrow for ischemic stroke therapy.
BACKGROUND AIMS Transplantation of mesenchymal stromal cells (MSC) derived from bone marrow (BM) or adipose tissue is expected to become a cell therapy for stroke. The present study compared theExpand
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