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Functional venomics of the Sri Lankan Russell's viper (Daboia russelii) and its toxinological correlations.
TLDR
The proteome correlates with the functional and toxinological characterizations of the venom, and reflects the pathophysiological effects of envenomation by the Sri Lankan Russell's viper. Expand
A Simple and Novel Strategy for the Production of a Pan-specific Antiserum against Elapid Snakes of Asia
TLDR
A pan-specific antiserum effective against major medically important elapids in Asia is produced to reduce the number of antigens the horses were exposed to and could be produced economically in large volume for use in many countries and save many lives. Expand
Antivenom Cross-Neutralization of the Venoms of Hydrophis schistosus and Hydrophis curtus, Two Common Sea Snakes in Malaysian Waters
TLDR
Investigating the cross-neutralizing potential of three regionally produced anti-cobra antivenoms against the venoms of Malaysian H. schistosus and H. curtus revealed the potential of NPAV as a second-line treatment for sea snake envenomation in the region. Expand
Venomics, lethality and neutralization of Naja kaouthia (monocled cobra) venoms from three different geographical regions of Southeast Asia.
TLDR
Despite the proteomic variations, the use of Thai monovalent and polyvalent antivenoms for N. kaouthia envenomation in the three regions is appropriate as the different venoms were neutralized by the antivenom albeit at different degrees of effectiveness, supporting their uses in theThree populations. Expand
Venom-gland transcriptome and venom proteome of the Malaysian king cobra (Ophiophagus hannah)
TLDR
The diversity and abundance of toxins in the venom of the Malaysian king cobra (MOh) are reported, and the results correlate with the pathophysiological actions of MOh venom, and dispute the use of Naja cobra antivenoms to treat MOh envenomation. Expand
Elucidating the biogeographical variation of the venom of Naja naja (spectacled cobra) from Pakistan through a venom-decomplexing proteomic study.
Naja naja is a medically important species that is distributed widely in South Asia. Its venom lethality and neutralization profile have been reported to vary markedly, but the understanding of thisExpand
Venom proteome of Bungarus sindanus (Sind krait) from Pakistan and in vivo cross-neutralization of toxicity using an Indian polyvalent antivenom.
TLDR
The findings imply that B. sindanus and the phylogenetically related B. caeruleus of India share certain venom epitopes, and may be considered in the formulation of a more effective pan-regional, polyspecific antivenom. Expand
Chick embryo chorioallantoic membrane (CAM): an alternative predictive model in acute toxicological studies for anti-cancer drugs
TLDR
The chick embryo may be a suitable alternative model for acute drug toxicity screening before embarking on full toxicological investigations in rodents in development of anticancer drugs. Expand
Assessing SABU (Serum Anti Bisa Ular), the sole Indonesian antivenom: A proteomic analysis and neutralization efficacy study
TLDR
The findings indicate that the production of SABU warrants further improvement, and implies that a large antivenom dose is required clinically for effective treatment. Expand
Proteomics, functional characterization and antivenom neutralization of the venom of Pakistani Russell's viper (Daboia russelii) from the wild.
TLDR
A unique venom proteome of the Pakistani D. russelii from the wild is revealed, in which PLA2 predominated (~60% of total venom proteins), in which the antivenom neutralized the toxicity of the wild Pakistani Russell's viper venom at moderate efficacies. Expand
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