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Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels.
TLDR
Serotonin transporter binding sites were regulated in a region-specific and substance-specific pattern, which was not simply a local response to functional blockade, and it is possible that serotonin transporter promoter genotype may play a complex role in chronic ethanol dependence.
Serotonin transporter promoter polymorphism, peripheral indexes of serotonin function, and personality measures in families with alcoholism.
TLDR
The results of this pilot study suggest that further work should examine the mediation of the genetic effects on personality traits by biochemical measures and their moderation by gender.
Cocaine induction of dopamine transporter trafficking to the plasma membrane.
TLDR
The present model system may further the understanding of regulatory alterations in DAT radioligand binding and function caused by cocaine exposure and Immunofluorescence and biotinylation experiments indicated that cocaine treatment induced increases in plasma membrane DAT immunoreactivity and intracellular decreases.
Dopamine Receptor Gene Expression in the Human Medial Temporal Lobe
TLDR
The results provide a description of the distribution of these receptor mRNAs in normal humans and suggest multiple levels of complexity as well as regulation of the medial temporal lobe dopamine projection.
Striatal dopaminergic abnormalities in human cocaine users.
TLDR
The present results confirm that cocaine users have a high number of dopamine transporter binding sites on dopaminergic neurons, despite an apparent low number of total dopamine terminals.
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