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Multi-Toxic Endpoints of the Foodborne Mycotoxins in Nematode Caenorhabditis elegans
TLDR
The lethality endpoint was more sensitive for T-2 toxicity with the EC50 at 1.38 mg/L, the growth endpoint was relatively sensitive for AFB1 toxic effects, and the reproduction endpoint wasMore sensitive for toxicities of AFB1, FB1, and ZEA. Expand
Biological detoxification of zearalenone by Aspergillus niger strain FS10.
TLDR
R Rats administered with contaminated corn steep liquor treated with the strain FS10 culture filtrate showed significantly less severe liver and kidney damage, and organ index values were comparable to the non-ZEN-exposed control (p<0.05); this study suggests an effective approach to reduce the hazards of ZEN in corn steep alcohol. Expand
Maternal aflatoxin exposure during pregnancy and adverse birth outcomes in Uganda
TLDR
The data suggest an association between maternal aflatoxin exposure during pregnancy and adverse birth outcomes, particularly lower birth weight and smaller head circumference, but further research is warranted. Expand
Mitigation of Oxidative Damage by Green Tea Polyphenols and Tai Chi Exercise in Postmenopausal Women with Osteopenia
TLDR
GTP and TC interventions were effective strategies of reducing the levels of oxidative stress, a putative mechanism for osteoporosis in postmenopausal women, and more importantly, working in an additive manner, which holds the potential as alternative tools to improve bone health in this population. Expand
Calcium montmorillonite clay reduces AFB1 and FB1 biomarkers in rats exposed to single and co‐exposures of aflatoxin and fumonisin
TLDR
UPSN significantly reduced bioavailability of both AFB1 and FB1 when in combination; suggesting that it can be utilized to reduce levels below their respective thresholds for affecting adverse biological effects. Expand
Aflatoxin B1-lysine adduct in dried blood spot samples of animals and humans.
TLDR
Results showed AFB1-lysine adduct levels in DBS cards and serum samples from animals and human samples are comparable, and the DBS technique and analytical protocol is a good means to assess AFB1 exposure in infant and children populations. Expand
Sequential dietary exposure to aflatoxin B1 and fumonisin B1 in F344 rats increases liver preneoplastic changes indicative of a synergistic interaction.
Dietary co-exposure to aflatoxin B1 (AFB1) and fumonisin B1 (FB1) and their interaction on hepatocellular carcinogenesis is of particular concern in toxicology and public health. In this study weExpand
Trans-/multi-generational effects of deoxynivalenol on Caenorhabditis elegans.
TLDR
It is demonstrated that DON exposure produced significant trans-/multi-generational toxic effects on C.elegans, which may serve as a model organism to explore molecular mechanisms of long-term adverse health effects of DON, which is one of the most widely distributed trichothecene mycotoxins commonly found in cereal food and feeds. Expand
Intervention trial with calcium montmorillonite clay in a south Texas population exposed to aflatoxin
TLDR
The observed effect in the low-dose treatment group suggests that the use of ACCS100 may be a viable strategy to reduce dietary AFB1 bioavailability during aflatoxin outbreaks and potentially in populations chronically exposed to this carcinogen. Expand
Toxicogenomic responses to zearalenone in Caenorhabditis elegans reveal possible molecular mechanisms of reproductive toxicity.
TLDR
The results demonstrate that disruption of the collagen biosynthetic pathway might be a key mechanism in ZEA-induced reproductive and developmental toxic effects in C. elegans. Expand
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