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Characteristics of orphan drug applications that fail to achieve marketing approval in the USA.
The US Orphan Drug Act has fostered the development of drugs for patients with rare diseases by granting 'orphan designations', although several orphan drugs for which a marketing application hasExpand
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Urban flooding risk assessment based on an integrated k-means cluster algorithm and improved entropy weight method in the region of Haikou, China
TLDR
An integrated methodology is proposed by incorporating urban flood inundation model, improved entropy weight method and k-means cluster algorithm to evaluate urban flood risk in Haikou, China. Expand
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CHAT: a conversational helper for automotive tasks
TLDR
We develop a robust, wide-coverage, and cognitive load-sensitive spoken dialog interface called CHAT: Conversational Helper for Automotive Tasks. Expand
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Drivers of macrofungal composition and distribution in Yulong Snow Mountain, southwest China
Although environmental factors strongly affect the distribution of macrofungi, few studies have so far addressed this issue. Therefore, to further our understanding of how macrofungi respond toExpand
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Failure probability assessment of gas transmission pipelines based on historical failure-related data and modification factors
TLDR
An assessment model of gas transmission pipelines failure probability based on historical failure-related data and modification factors is established. Expand
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Combination of acid β-glucosidase mutation and Saposin C deficiency in mice reveals Gba1 mutation dependent and tissue-specific disease phenotype
Gaucher disease is caused by mutations in GBA1 encoding acid β-glucosidase (GCase). Saposin C enhances GCase activity and protects GCase from intracellular proteolysis. Structure simulationsExpand
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A Flexible Conversational Dialog System for MP3 Player
TLDR
In recent years, an increasing number of new devices have found their way into the cars we drive. Expand
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Optimal management of the flooding risk caused by the joint occurrence of extreme rainfall and high tide level in a coastal city
Coastal cities are more vulnerable to floods due to the joint impact of rainfall and tide level. Quantitative risk assessment of disaster-causing factors is critical to urban flood management. ThisExpand
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Water Price Prediction for Increasing Market Efficiency Using Random Forest Regression: A Case Study in the Western United States
The existence of water markets establishes water prices, promoting trading of water from low- to high-valued uses. However, market participants can face uncertainty when asking and offering pricesExpand
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CGDNA: 基于簇图的基因组序列集成拼接算法 (CGDNA: An Ensemble De Novo Genome Assembly Algorithm Based on Clustering Graph)
TLDR
The experimental results demonstrate that by implementing the CGDNA algorithm,two standard metrics(the largest scaffold and scaffold N50)are increased by 50 when compared to the state-of-the-art algorithms,i.e.,Velvet,AByS ,and SOAPdenovo.Moreover,the per— form ance of CG DNA algorithm should be further improved when more base algorithms are added. Expand