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Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia
A highly pathogenic avian influenza virus, H5N1, caused disease outbreaks in poultry in China and seven other east Asian countries between late 2003 and early 2004; the same virus was fatal to humans… Expand
Translation elongation factor 1A is a component of the tombusvirus replicase complex and affects the stability of the p33 replication co-factor.
Host RNA-binding proteins are likely to play multiple, integral roles during replication of plus-strand RNA viruses. To identify host proteins that bind to viral RNAs, we took a global approach based… Expand
Identification, sequence, and expression of the gene encoding gamma-glutamyltranspeptidase in Bacillus subtilis.
The Bacillus subtilis gene encoding gamma-glutamyltranspeptidase (GGT) activity encodes a protein of 587 amino acids having extensive homologies with other procaryotic GGTs. Inactivation of the gene… Expand
Repurposing CRISPR-Cas12b for mammalian genome engineering
The prokaryotic CRISPR-Cas adaptive immune systems provide valuable resources to develop genome editing tools, such as CRISPR-Cas9 and CRISPR-Cas12a/Cpf1. Recently, CRISPR-Cas12b/C2c1, a distinct… Expand
Overexpression of AtNHX1, a Vacuolar Na+/H+ Antiporter from Arabidopsis thalina, in Petunia hybrida Enhances Salt and Drought Tolerance
Plant Na+/H+ antiporter plays a critical role in plant salt tolerance. In this study, AtNHX1, a vacuolar Na+/H+ antiporter from Arabidopsis thalina, was introduced into Petunia hybrida using… Expand
RNA virus replication depends on enrichment of phosphatidylethanolamine at replication sites in subcellular membranes
Significance Positive-strand RNA viruses are major pathogens of plants, animals, and humans. These viruses subvert intracellular membranes for virus replication, and lipids are critical due to… Expand
Site occupancy and glycan compositional analysis of two soluble recombinant forms of the attachment glycoprotein of Hendra virus.
Hendra virus (HeV) continues to cause morbidity and mortality in both humans and horses with a number of sporadic outbreaks. HeV has two structural membrane glycoproteins that mediate the infection… Expand
Co-opted Oxysterol-Binding ORP and VAP Proteins Channel Sterols to RNA Virus Replication Sites via Membrane Contact Sites
Viruses recruit cellular membranes and subvert cellular proteins involved in lipid biosynthesis to build viral replicase complexes and replication organelles. Among the lipids, sterols are important… Expand
Enhanced mammalian genome editing by new Cas12a orthologs with optimized crRNA scaffolds
CRISPR-Cas12a/Cpf1, a single RNA-guided endonuclease system, provides a promising tool for genome engineering. However, only three Cas12a orthologs have been employed for mammalian genome editing,… Expand
Proteome-Wide Overexpression of Host Proteins for Identification of Factors Affecting Tombusvirus RNA Replication: an Inhibitory Role of Protein Kinase C
- Muhammad Shah Nawaz-ul-Rehman, N. Martinez-Ochoa, +7 authors P. Nagy
- Biology, Medicine
- Journal of Virology
- 20 June 2012
ABSTRACT To identify host genes affecting replication of Tomato bushy stunt virus (TBSV), a small model positive-stranded RNA virus, we overexpressed 5,500 yeast proteins individually in… Expand