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Characterization of Functional Oligosaccharide Mimics of the Shigella flexneri Serotype 2a O-Antigen: Implications for the Development of a Chemically Defined Glycoconjugate Vaccine1
TLDR
It was demonstrated that induction of an efficient serotype 2a-specific anti-O-Ag Ab response was dependent on the length of the oligosaccharide sequence, which was a potential candidate for further development of a chemically defined glycoconjugate vaccine against S. flexneri 2a infection. Expand
Nucleotide-free kinesin hydrolyzes ATP with burst kinetics.
TLDR
Measurements of the dependence on ATP concentration of the steady state rate and amount of bound ADP are consistent with a Km of this magnitude. Expand
Conversion of glucosamine to galactosamine and allosamine derivatives: control of inversions of stereochemistry at C-3 and C-4.
The reactions of sodium benzoate with a series of trimesylates derived from glucosamine have been examined in an attempt to gain facile access to galactosamine analogues. Trimesylate 17, in which theExpand
Nuclear-magnetic-relaxation studies of the interaction of inhibitor with the threonine-sensitive aspartokinase of Escherichia coli.
TLDR
This 13C NMR study has located one of the two classes of threonine regulatory sites which exist per subunit; theThreonine site identified here is at the aspartokinase active site, adjacent to the catalytic metal site. Expand
Fluorescence energy transfer between heterologous active sites of affinity-labeled aspartokinase of Escherichia coli.
The distance between aspartokinase and homoserine dehydrogenase active sites was determined using fluorescence energy transfer between modified substrates. The fluorescent 1,N(6)-ethenoadenosineExpand
Induced axial chirality in the biphenyl core of the cα-tetrasubstituted α-amino acid residue Bip and subsequent propagation of chirality in (Bip)n/Val oligopeptides
In the dipeptides Boc-Bip-L-Val-OMe and Boc-Bip-D-Val-OMe, an induced axial chirality in the biphenyl core of the Bip residue, a conformationally labile, proatropoisomeric Cα,α-disubstituted glycine,Expand
The Bip method, based on the induced circular dichroism of a flexible biphenyl probe in terminally protected -Bip-Xaa*- dipeptides, for assignment of the absolute configuration of beta-amino acids.
TLDR
The Bip method was applied to the unique spin-labeled, cyclic, beta-amino acids cis/trans-beta-TOAC and trans-POAC and allowed the assignment of the unknown absolute configurations of the enantiomers of the latter compound. Expand
Copper-catalyzed cyclization of iodo-tryptophans: a straightforward synthesis of pyrroloindoles.
TLDR
Intramolecular copper-catalyzed coupling of readily accessible 2-iodo-tryptophan derivatives occurs in excellent yield, affording a wide range of polysubstituted, enantioenriched tetrahydropyrrolo[2,3- b]indoles. Expand
Novel liposaccharide conjugates for drug and peptide delivery.
TLDR
These preliminary experiments have demonstrated the ability of the liposaccharides to form particulate systems per se and also their ability to be incorporated into conventional liposomal systems. Expand
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