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Mechanisms of rejection: current perspectives.
TLDR
Identifying the molecular pathways that trigger tissue injury, signal transduction and rejection facilitates the identification of targets for the development of immunosuppressive drugs.
Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans.
TLDR
An immunological profile of the tolerant state is provided that, with further validation, should inform and shape drug-weaning protocols in renal transplant recipients.
CD25+CD4+ Regulatory T Cells Prevent Graft Rejection: CTLA-4- and IL-10-Dependent Immunoregulation of Alloresponses1
TLDR
Evidence is provided that pretreatment with anti-CD4 Ab plus a donor-specific transfusion generates donor- specific regulatory CD25+CD4+ T cells that can suppress rejection of skin grafts mediated by naive CD45RBhighCD4- T cells.
Regulatory immune cells in transplantation
TLDR
The leukocyte populations that can promote immune tolerance after cell or solid-organ transplantation are discussed, including regulatory T cells, B cells and macrophages, as well as myeloid-derived suppressor cells, dendritic cells and mesenchymal stromal cells.
Regulatory lymphocytes: Regulatory T cells in transplantation tolerance
TLDR
The origin, allorecognition properties and molecular basis for the suppressive activity of CD4+CD25+ TReg cells, as well as their relationship to other populations of regulatory cells that exist after transplantation, remain a matter of debate.
IL-33 Expands Suppressive CD11b+ Gr-1int and Regulatory T Cells, including ST2L+ Foxp3+ Cells, and Mediates Regulatory T Cell-Dependent Promotion of Cardiac Allograft Survival
TLDR
It is reported that IL-33 administration, while facilitating Th2 responses, also increases immunoregulatory myeloid cells and CD4+ Foxp3+ regulatory T cells (Tregs) in mice, revealing a new immunoreGulatory property of IL- 33.
Mesenchymal Stem Cells Prevent the Rejection of Fully Allogenic Islet Grafts by the Immunosuppressive Activity of Matrix Metalloproteinase-2 and -9
TLDR
MSCs can prevent islet allograft rejection leading to stable, long-term normoglycemia and provide a novel insight into the mechanism underlying the suppressive effects of MSCs on T-cell responses to alloantigen.
IFN-γ production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo
TLDR
A unique role for IFN-γ in the functional activity of alloantigen-reactive T reg cells during the development of operational tolerance to donor alloantsigens in vivo is supported.
Interferon gamma: a crucial role in the function of induced regulatory T cells in vivo.
TLDR
A model in which IFNgamma produced rapidly and only transiently by induced Treg cells is crucial to their function in vivo is proposed, which can directly inhibit the activation and proliferation of IFN GammaR1- and IFNGammaR2-bearing T cells.
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