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Calcium movements, distribution, and functions in smooth muscle.
Contraction of smooth muscle is regulated by the cytosolic Ca2+ level ([Ca2+]i)b, and the sensitivity to Ca2+ of the contractile elements in response to changes in the environment surrounding theExpand
Distribution of the vanilloid receptor (VR1) in the gastrointestinal tract
VR1‐like immunoreactivity was found in several locations within the GI tract and may provide sensory integration of chemical, physical, or inflammatory stimuli. Expand
Upregulation of iNOS by COX-2 in muscularis resident macrophage of rat intestine stimulated with LPS.
  • M. Hori, M. Kita, +5 authors H. Karaki
  • Biology, Medicine
  • American journal of physiology. Gastrointestinal…
  • 1 May 2001
Findings show that LPS increases iNOS expression and stimulates NO production in muscularis resident macrophages to inhibit smooth muscle contraction. Expand
Interstitial cells of Cajal mediate mechanosensitive responses in the stomach.
A previously uncharacterized nonneural stretch reflex in gastric muscles is demonstrated and physiological evidence demonstrating a mechanosensitive role for interstitial cells of Cajal in smooth muscle tissues is provided. Expand
Motility disorder in experimentally obstructed intestine: relationship between muscularis inflammation and disruption of the ICC network
Under the pro‐inflammatory conditions of the tunica muscularis associated with intestinal obstruction, the release of bioactive substances, possibly from activated resident macrophages, may affect smooth muscle contractility and both the number and the function of neighbouring ICC may also be affected. Expand
Muscularis inflammation and the loss of interstitial cells of Cajal in the endothelin ETB receptor null rat.
Results suggest that ED2-positive resident macrophages may play an important role in the inflammation of tunica muscularis in ETB(-/-) rats, and may result in damage to ICC networks leading to disordered intestinal rhythmicity in regions of the gut in which myenteric ganglia are intact. Expand
DJ-1 protein regulates CD3+ T cell migration via overexpression of CXCR4 receptor.
DJ-1 protein is involved in the SDF-1-induced CD3+ T cell migration via overexpression of the CXCR4 receptor, and that DJ-1 acts as an inhibitory regulator in vascular remodeling such as neointima formation. Expand
Proteomic profiling and identification of cofilin responding to oxidative stress in vascular smooth muscle
The results suggest that cofilin is one of the proteins regulated by H2O2 treatment in vascular smooth muscle, and has an important role in the induction of vascular apoptosis through PTP‐dependent mechanisms. Expand
Isolation and characterization of resident macrophages from the smooth muscle layers of murine small intestine
It is suggested that resident macrophages in the intestine may play a role in the immunological protection of the gut and expressed a proton conductance that may participate in pH maintenance during reactive oxygen production. Expand
Endothelin-1 induces contraction via a Syk-mediated p38 mitogen-activated protein kinase pathway in rat aortic smooth muscle.
Results suggest that spleen tyrosine kinase may play an important role in the regulation of aortic smooth muscle contraction induced by ET-1, which may be mediated by the p38 MAPK/HSP27 signaling pathway. Expand