POU5F1 (OCT3/4) identifies cells with pluripotent potential in human germ cell tumors.
- L. Looijenga, H. Stoop, J. Oosterhuis
- Medicine, BiologyCancer Research
- 1 May 2003
Results indicate preservation of the link between POU5F1 and pluripotency, as reported during normal development, after malignant transformation of GCT and the histological heterogeneity of this cancer.
Germ cell tumors in the intersex gonad: old paths, new directions, moving frontiers.
- M. Cools, S. Drop, K. Wolffenbuttel, J. Oosterhuis, L. Looijenga
- MedicineEndocrine reviews
- 25 May 2006
A new classification system for patients with DSD is proposed as a tool to refine insight in the prevalence of germ cell tumors in specific diagnostic groups and the correct diagnosis of early neoplastic lesions in this patient population.
Tumor risk in disorders of sex development (DSD).
- L. Looijenga, R. Hersmus, J. Oosterhuis, M. Cools, S. Drop, K. Wolffenbuttel
- MedicineBest practice & research. Clinical endocrinology…
- 1 September 2007
Gonadoblastoma arising in undifferentiated gonadal tissue within dysgenetic gonads.
- M. Cools, H. Stoop, L. Looijenga
- Medicine, BiologyJournal of Clinical Endocrinology and Metabolism
- 15 June 2006
It is hypothesized that gonadoblastomas originate from surviving OCT3/4-positive germ cells in areas of undifferentiated gonadal tissue within the dysgenetic gonad, and supportive evidence was obtained that carcinoma in situ arises in regions with testicular differentiation.
Identification of germ cells at risk for neoplastic transformation in gonadoblastoma: an immunohistochemical study for OCT3/4 and TSPY.
- A. Kersemaekers, F. Honecker, L. Looijenga
- Medicine, BiologyHuman Pathology
- 1 May 2005
Gonadal pathology and tumor risk in relation to clinical characteristics in patients with 45,X/46,XY mosaicism.
- M. Cools, J. Pleskacová, K. Wolffenbuttel
- MedicineJournal of Clinical Endocrinology and Metabolism
- 20 April 2011
The hypothesis that gonadal histology and risk for development of a malignant germ cell tumor are reflected by the clinical presentation of a 45,X/46,XY individual is tested and it is found that the EMS reflects gonadal differentiation and tumor risk in patients with 45, X/ 46,XY.
Tumor Risk in Disorders of Sex Development
- J. Pleskacová, R. Hersmus, L. Looijenga
- Medicine, BiologySexual Development
- 17 June 2010
Certain patients with disorders of sex development (DSD), who bear Y chromosome material in their karyotype, are at increased risk for the development of type II germ cell tumors (GCT), which arise…
Surgery in disorders of sex development (DSD) with a gender issue: If (why), when, and how?
- P. Mouriquand, D. Gorduza, Peter Lee
- MedicineJournal of Pediatric Urology
- 1 June 2016
Morphological and immunohistochemical differences between gonadal maturation delay and early germ cell neoplasia in patients with undervirilization syndromes.
- M. Cools, K. V. van Aerde, L. Looijenga
- MedicineJournal of Clinical Endocrinology and Metabolism
- 1 September 2005
Abnormal OCT3/4 and testis-specific protein Y encoded expression appear to be of pathogenetic relevance in the development of these lesions and are proposed as an alternative for gonadectomy.
Isolated 17,20-lyase deficiency due to the cytochrome b5 mutation W27X.
- Renée C Kok, M. Timmerman, K. Wolffenbuttel, S. Drop, F. de Jong
- Biology, MedicineJournal of Clinical Endocrinology and Metabolism
- 1 March 2010
The findings provide evidence for an alternative etiology for this disorder and demonstrate 17,20-lyase deficiency due to an aberrant CytB5.
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