Share This Author
Stimulation of the lateral habenula inhibits dopamine-containing neurons in the substantia nigra and ventral tegmental area of the rat
- G. R. Christoph, R. Leonzio, K. Wilcox
- BiologyThe Journal of neuroscience : the official…
- 1 March 1986
It is shown that activation of neuronal perikarya in the LHb causes orthodromic inhibition of dopamine-containing neurons in SNC and VTA via the fasciculus retroflexus.
Calcium-Dependent Paired-Pulse Facilitation of Miniature EPSC Frequency Accompanies Depression of EPSCs at Hippocampal Synapses in Culture
It was found that an increase in miniature EPSC frequency accompanied both single and multiple stimuli, and this mEPSC increase was facilitated during paired stimuli, even when the evoked synchronous release was depressed.
Discovery of antiepileptic drugs
Paired pulse depression in cultured hippocampal neurons is due to a presynaptic mechanism independent of GABAB autoreceptor activation
The results indicate that, under baseline conditions, the quantal content for IPSCs is relatively large for a single action potential, but thequantal content rapidly decreases, such that subsequent action potentials consistently result in much smaller IPSCs for periods as long as 4 sec.
Imaging Activity in Neurons and Glia with a Polr2a-Based and Cre-Dependent GCaMP5G-IRES-tdTomato Reporter Mouse
A rat brain slice preparation for characterizing both thalamostriatal and corticostriatal afferents
Electrophysiological properties of neurons in the lateral habenula nucleus: an in vitro study.
The ability of lateral habenula neurons to fire action potentials in two modes, tonically and in bursts, and the propensity of these neurons to dramatically alter their output in response to transient hyperpolarizing input, indicate that transmission through this relay in the dorsal diencephalic conduction system may be greatly augmented by relatively small hyperPolarizing influences on the individual neurons.
Mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization
These novel knockin mice recapitulate proconvulsant features of the human disorder yet show that inherited M‐current defects spare granule cells from reactive changes in adult hippocampal networks.
Differences in excitatory transmission between thalamic and cortical afferents to single spiny efferent neurons of rat dorsal striatum
The striatum is crucially involved in motor and cognitive function, and receives significant glutamate input from the cortex and thalamus. The corticostriatal pathway arises from diverse regions of…
Seizures following picornavirus infection
A novel virus infection‐induced seizure model in C57BL/6 mice is demonstrated and characterized for the first time and its establishment and characterization are demonstrated.