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Neuroanatomy of the pain system and of the pathways that modulate pain.
We review many of the recent findings concerning mechanisms and pathways for pain and its modulation, emphasizing sensitization and the modulation of nociceptors and of dorsal horn nociceptiveExpand
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Excitatory amino acid receptor involvement in peripheral nociceptive transmission in rats.
The involvement of excitatory amino acid receptors in peripheral nociceptive processing was assessed in two separate experiments. In the first, one knee joint cavity of rats was injected with 0.1 mlExpand
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The efferent projections of the periaqueductal gray in the rat: A Phaseolus vulgaris‐leucoagglutinin study. II. Descending projections
The descending projections of the periaqueductal gray (PAG) have been studied in the rat using the anterograde tracer Phaseolus vulgaris‐leucoagglutinin. The tracer was injected into the dorsolateralExpand
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Noradrenergic projections to the spinal cord of the rat
Noradrenergic terminals were identified in the spinal cord of rats by immunocytochemical staining for dopamine-beta-hydroxylase. Although immunoreactive fibers and terminals were observed throughoutExpand
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Descending projections of the locus coeruleus and subcoeruleus/medial parabrachial nuclei in monkey: Axonal transport studies and dopamine-β-hydroxylase immunocytochemistry
Spinal projections originating in the dorsolateral pons in the ventral locus coeruleus and in the subcoeruleus and medial parabrachial nuclei were identified in monkeys (Macaca fascicularis) usingExpand
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Visceral nociceptive input into the ventral posterolateral nucleus of the thalamus: a new function for the dorsal column pathway.
1. Extracellular recordings were made from single neurons in the ventral posterolateral (VPL) nucleus of the thalamus in anesthetized male rats. VPL cells that responded to colorectal distensionExpand
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Rodent model of chronic central pain after spinal cord contusion injury and effects of gabapentin.
Spinal cord injury (SCI) often results in abnormal pain syndromes in patients. We present a recently developed SCI mammalian model of chronic central pain in which the spinal cord is contused at T8Expand
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Transdermal cannabidiol reduces inflammation and pain‐related behaviours in a rat model of arthritis
Current arthritis treatments often have side‐effects attributable to active compounds as well as route of administration. Cannabidiol (CBD) attenuates inflammation and pain without side‐effects, butExpand
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Distinct monoamine oxidase A and B populations in primate brain.
Monoclonal antibodies specific for monoamine oxidase (MAO) A and MAO B, respectively, were used to localize these enzymes in primate brain. The reagents recognized different populations of neurons:Expand
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The efferent projections of the periaqueductal gray in the rat: A Phaseolus vulgaris‐leucoagglutinin study. I. Ascending projections
This study has examined the ascending projections of the periaqueductal gray in the rat. Injections of Phaseolus vulgaris‐leucoagglutinin were placed in the dorsolateral or ventrolateral subregions,Expand
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