Structure and function of a squalene cyclase.
- K. Wendt, K. Poralla, G. Schulz
- Chemistry, BiologyScience
- 19 September 1997
The crystal structure of squalene-hopene cyclase from Alicyclobacillus acidocaldarius was determined and reveals a membrane protein with membrane-binding characteristics similar to those of prostaglandin-H2 synthase, the only other reported protein of this type.
NMR characterization of kinase p38 dynamics in free and ligand-bound forms.
- M. Vogtherr, K. Saxena, H. Schwalbe
- Chemistry, MedicineAngewandte Chemie
- 30 January 2006
The structure of the membrane protein squalene-hopene cyclase at 2.0 A resolution.
- K. Wendt, A. Lenhart, G. Schulz
- Chemistry, BiologyJournal of Molecular Biology
- 12 February 1999
The structure of the enzyme from Alicyclobacillus acidocaldarius has been determined and the membrane-binding interactions of which are described and compared with those of two prostaglandin-H2 synthase isoenzymes, the only other structurally characterized proteins of this type.
DOTAM derivatives as active cartilage-targeting drug carriers for the treatment of osteoarthritis.
A small multivalent structure as a model drug for the attenuation of cartilage degradation and successfully reduced the cathepsin D protease activity as measured by release of GAG peptide represent a promising first drug conjugate for the targeted treatment of degenerative joint diseases.
Enzyme Mechanisms for Polycyclic Triterpene Formation
- K. Wendt, G. Schulz, E. Corey, David R. Liu
- Chemistry
- 14 November 2000
A comparative analysis of the immunological evolution of antibody 28B4.
- J. Yin, E. Mundorff, P. Schultz
- BiologyBiochemistry
- 11 September 2001
The germline antibody of 28B4 acquired functionally important mutations in a stepwise manner, which fits into a multicycle mutation, affinity selection, and clonal expansion model for germline antibodies evolution.
In Vivo Imaging of Mouse Tumors by a Lipidated Cathepsin S Substrate**
- Hai‐Yu Hu, D. Vats, Carsten Schultz
- Biology, ChemistryAngewandte Chemie
- 30 May 2014
The lipidated probe provided a prolonged and strongly fluorescent signal in tumors when compared to the very similar non-lipidated probe, demonstrating that non-invasive tumor identification is feasable.
Acyl ureas as human liver glycogen phosphorylase inhibitors for the treatment of type 2 diabetes.
- T. Klabunde, K. Wendt, E. Defossa
- Chemistry, BiologyJournal of Medicinal Chemistry
- 9 September 2005
Findings are consistent with the inhibition of hepatic glycogenolysis and support the use of acyl ureas for the treatment of type 2 diabetes.
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