Structure and function of a squalene cyclase.
The crystal structure of squalene-hopene cyclase from Alicyclobacillus acidocaldarius was determined and reveals a membrane protein with membrane-binding characteristics similar to those of prostaglandin-H2 synthase, the only other reported protein of this type.
Structural basis for the highly selective inhibition of MMP-13.
NMR characterization of kinase p38 dynamics in free and ligand-bound forms.
The structure of the membrane protein squalene-hopene cyclase at 2.0 A resolution.
The structure of the enzyme from Alicyclobacillus acidocaldarius has been determined and the membrane-binding interactions of which are described and compared with those of two prostaglandin-H2 synthase isoenzymes, the only other structurally characterized proteins of this type.
DOTAM derivatives as active cartilage-targeting drug carriers for the treatment of osteoarthritis.
A small multivalent structure as a model drug for the attenuation of cartilage degradation and successfully reduced the cathepsin D protease activity as measured by release of GAG peptide represent a promising first drug conjugate for the targeted treatment of degenerative joint diseases.
Enzyme Mechanisms for Polycyclic Triterpene Formation
Isoprenoid biosynthesis: manifold chemistry catalyzed by similar enzymes.
A comparative analysis of the immunological evolution of antibody 28B4.
The germline antibody of 28B4 acquired functionally important mutations in a stepwise manner, which fits into a multicycle mutation, affinity selection, and clonal expansion model for germline antibodies evolution.
In Vivo Imaging of Mouse Tumors by a Lipidated Cathepsin S Substrate**
The lipidated probe provided a prolonged and strongly fluorescent signal in tumors when compared to the very similar non-lipidated probe, demonstrating that non-invasive tumor identification is feasable.
Acyl ureas as human liver glycogen phosphorylase inhibitors for the treatment of type 2 diabetes.
Findings are consistent with the inhibition of hepatic glycogenolysis and support the use of acyl ureas for the treatment of type 2 diabetes.