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Inflammation, stress, and diabetes.
Over the last decade, an abundance of evidence has emerged demonstrating a close link between metabolism and immunity. It is now clear that obesity is associated with a state of chronic low-level… Expand
ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation
- K. Wellen, G. Hatzivassiliou, Uma M. Sachdeva, Thi V Bui, J. Cross, C. Thompson
- Biology, Medicine
- 22 May 2009
Chromatin Modifier Modulates Gene Expression Modification of chromatin structure is usually thought of as a global, relatively nonspecific way of modulating gene expression. However, Wellen et al.… Expand
IDH mutation impairs histone demethylation and results in a block to cell differentiation
Recurrent mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 have been identified in gliomas, acute myeloid leukaemias (AML) and chondrosarcomas, and share a novel enzymatic property of… Expand
Obesity-induced inflammatory changes in adipose tissue.
Obesity is associated with a state of chronic, low-grade inflammation. Two manuscripts in this issue of the JCI (see the related articles beginning on pages 1796 and 1821) now report that obese… Expand
Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence
Cellular senescence both protects multicellular organisms from cancer and contributes to their ageing. The pre-eminent tumour suppressor p53 has an important role in the induction and maintenance of… Expand
Cellular metabolic stress: considering how cells respond to nutrient excess.
Nutrient stress is generally considered from the standpoint of how cells detect and respond to an insufficient supply of nutrients to meet their bioenergetic needs. However, cells also experience… Expand
Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation.
Histone acetylation plays important roles in gene regulation, DNA replication, and the response to DNA damage, and it is frequently deregulated in tumors. We postulated that tumor cell histone… Expand
Coordinated Regulation of Nutrient and Inflammatory Responses by STAMP2 Is Essential for Metabolic Homeostasis
Metabolic and inflammatory pathways crosstalk at many levels, and, while required for homeostasis, interaction between these pathways can also lead to metabolic dysregulation under conditions of… Expand
Metabolic reprogramming in cancer: unraveling the role of glutamine in tumorigenesis.
Increased glutaminolysis is now recognized as a key feature of the metabolic profile of cancer cells, along with increased aerobic glycolysis (the Warburg effect). In this review, we discuss the… Expand
Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis
During the progression of pancreatic ductal adenocarcinoma (PDAC), heterogeneous subclonal populations emerge that drive primary tumor growth, regional spread, distant metastasis, and patient death.… Expand