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Iron autoxidation and free radical generation: effects of buffers, ligands, and chelators.
This study confirmed that the rate of Fe(II) autoxidation increases as the pH of the solution is increased, but chelators that provide oxygen ligands for the iron can override the affect of pH, and ferrous iron was shown to be able to directly reduce some quinones without the reduction of oxygen.
Antiparasitic Drug Nitazoxanide Inhibits the Pyruvate Oxidoreductases of Helicobacter pylori, Selected Anaerobic Bacteria and Parasites, and Campylobacter jejuni
It is proposed that NTZ− intercepts PFOR at an early step in the formation of the lactyl-TPP transition intermediate, resulting in the reversal of pyruvate binding prior to decarboxylation and in coordination with proton transfer to NTZ.
Deleterious iron-mediated oxidation of biomolecules.
Locoweed Poisoning in Livestock
Historically toxic species are divided into three groups based on the toxic syndromes observed in livestock: 1) selenium poisoning, 2) nitrotoxin poisoning, and 3) locoism caused by the toxin swainsonine.
Norditerpene alkaloid concentrations in tissues and floral rewards of larkspurs and impacts on pollinators
Role of IL-6 in an IL-10 and IL-4 double knockout mouse model uniquely susceptible to acetaminophen-induced liver injury.
Liver homeostasis following AILD appears to be highly dependent on the activities of both IL-10 and IL-4, which together help prevent overexpression of IL-6 and other potential hepatotoxic factors.
Poisonous plants: effects on embryo and fetal development.
- K. Panter, K. Welch, D. Gardner, B. Green
- MedicineBirth defects research. Part C, Embryo today…
- 1 December 2013
Plants that negatively impact embryo/fetal and neonatal growth and development, with emphasis on those plants that cause birth defects are reviewed.
Cyclopamine‐induced synophthalmia in sheep: defining a critical window and toxicokinetic evaluation
- K. Welch, K. Panter, S. T. Lee, D. Gardner, B. Stegelmeier, D. Cook
- MedicineJournal of applied toxicology : JAT
- 1 July 2009
The rapid clearance of cyclopamine indicates that ingestion of V. californicum must occur during a very narrow window for synophthalmia formation to occur.
Cyclopamine: from cyclops lambs to cancer treatment.
- S. Lee, K. Welch, K. Panter, D. Gardner, M. Garrossian, C. Chang
- BiologyJournal of agricultural and food chemistry
- 22 April 2014
In the late 1960s, the steroidal alkaloid cyclopamine was isolated from the plant Veratrum californicum and identified as the teratogen responsible for craniofacial birth defects including cyclops in…
Stereoselective potencies and relative toxicities of coniine enantiomers.
- S. Lee, B. Green, K. Welch, J. Pfister, K. Panter
- Chemistry, BiologyChemical research in toxicology
- 3 September 2008
The results from this study demonstrate that there is a stereoselective difference in the in vitro potencies of the enantiomers of coniine that directly correlates with the relative toxicities of theEnantiomers in vivo.