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Gene expression profiling in the leukemic stem cell-enriched CD34+ fraction identifies target genes that predict prognosis in normal karyotype AML
In order to identify acute myeloid leukemia (AML) CD34+-specific gene expression profiles, mononuclear cells from AML patients (n=46) were sorted into CD34+ and CD34− subfractions, and genome-wideExpand
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Heterogeneity in simvastatin-induced cytotoxicity in AML is caused by differences in Ras-isoprenylation
Heterogeneity in simvastatin-induced cytotoxicity in AML is caused by differences in Ras-isoprenylation
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Genetic risk factors for clozapine-induced neutropenia and agranulocytosis in a Dutch psychiatric population
Prescription of clozapine is complicated by the occurrence of clozapine-induced reduction of neutrophils. The aim of this study was to identify genetic risk factors in a population of 310 DutchExpand
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Variability in responsiveness to lovastatin of the primitive CD34+ AML subfraction compared to normal CD34+ cells
In the present study, we questioned whether the cholesterol synthesis inhibitor lovastatin potentiates the cytotoxicity of chemotherapeutic agents in the primitive CD34+ subpopulation of acuteExpand
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The association between CYP2D6 genotype and switching antipsychotic medication to clozapine
PurposeGenetic variation in the cytochrome P450 2D6 (CYP2D6) enzyme is responsible for interindividual differences in the metabolism of many antipsychotic drugs, but the clinical relevance ofExpand
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Heterogeneity in Simvastatin-Induced Cytotoxicity in AML Is Related to Differential Ras-Isoprenylation, Rather Than to Blockade of Cholesterol Synthesis.
Abstract 1718 Poster Board I-744 Introduction Cholesterol synthesis is enhanced in blast cells of acute myeloid leukemia (AML) patients, as indicated by high mRNA levels of 3-hydroxy-3-methylglutarylExpand
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Combining Simvastatinwith the Farnesyltransferase Inhibitor Tipifarnib Results in an Enhanced Cytotoxic Effect in a Subset of Primary CD 34 + AcuteMyeloid Leukemia Samples
Purpose: To show whether the inhibitory effects of the cholesterol synthesis inhibitor simvastatinonhumanCD34 acutemyeloid leukemia (AML) cells canbe further promotedby combining it with theExpand
The use of statins in acute myeloid leukemia
The mevalonate pathway is of crucial importance for the maintenance of cellular cholesterol homeostasis. It takes care of adequate cholesterol production to balance variations in cholesterol uptakeExpand