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Functional mapping and annotation of genetic associations with FUMA
TLDR
We introduce FUMA, a web-based bioinformatics tool that uses a combination of positional, eQTL and chromatin interaction mapping to prioritize likely causal variants and genes. Expand
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Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk
Alzheimer’s disease (AD) is highly heritable and recent studies have identified over 20 disease-associated genomic loci. Yet these only explain a small proportion of the genetic variance, indicatingExpand
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Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence
Intelligence is highly heritable1 and a major determinant of human health and well-being2. Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in intelligence3–7, butExpand
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Erratum: Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence
textabstractIntelligence is associated with important economic and health-related life outcomes. Despite intelligence having substantial heritability (0.54) and a confirmed polygenic nature, initialExpand
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Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways
Neuroticism is an important risk factor for psychiatric traits, including depression1, anxiety2,3, and schizophrenia4–6. At the time of analysis, previous genome-wide association studies7–12 (GWAS)Expand
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Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits
Persistent insomnia is among the most frequent complaints in general practice. To identify genetic factors for insomnia complaints, we performed a genome-wide association study (GWAS) and aExpand
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IRIS, Hinode, SDO, and RHESSI observations of a white light flare produced directly by non-thermal electrons
An X1.6 flare occurred in AR 12192 on 2014 October 22 at 14:02 UT and was observed by Hinode, IRIS, SDO, and RHESSI. We analyze a bright kernel which produces a white light (WL) flare with continuumExpand
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Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways
Insomnia is the second most prevalent mental disorder, with no sufficient treatment available. Despite substantial heritability, insight into the associated genes and neurobiological pathways remainsExpand
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Statistical Studies of Solar White-light Flares and Comparisons with Superflares on Solar-type Stars
Recently, many superflares on solar-type stars were discovered as white-light flares (WLFs). A correlation between the energies (E) and durations (t) of superflares is derived as $t\propto E^{0.39}$,Expand
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Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior
Importance Antisocial behavior (ASB) places a large burden on perpetrators, survivors, and society. Twin studies indicate that half of the variation in this trait is genetic. Specific causal geneticExpand
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