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Glypican‐4 is an FGF2‐binding heparan sulfate proteoglycan expressed in neural precursor cells
FGF2 is a crucial mitogen for neural precursor cells in the developing cerebral cortex. Heparan sulfate proteoglycans (HSPGs) are thought to play a role in cortical neurogenesis by regulating theExpand
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Lack of genetic association between TREM2 and late-onset Alzheimer's disease in a Japanese population.
Rare non-synonymous variants of TREM2 have recently been shown to be associated with Alzheimer's disease (AD) in Caucasians. We here conducted a replication study using a well-characterized JapaneseExpand
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Beta-hydroxybutyrate, an endogenic NLRP3 inflammasome inhibitor, attenuates stress-induced behavioral and inflammatory responses
Neuro-inflammation has been shown to play a critical role in the development of depression. Beta-hydroxybutyrate (BHB) is a ketone body and has recently been reported to exert anti-inflammatoryExpand
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MAGE-D1 regulates expression of depression-like behavior through serotonin transporter ubiquitylation.
The ubiquitin-proteasome system (UPS) controls the stability of most cellular proteins. The polymorphism of UPS-related genes is associated with major depression disorder, but less is known about theExpand
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[Paroxysmal perceptual alteration in comparison with hallucination--a review of its clinical reports and discussion of its pathophysiological mechanism in the present day, when second generation
  • K. Watanabe
  • Medicine
  • Seishin shinkeigaku zasshi = Psychiatria et…
  • 2009
The syndrome of paroxysmal perceptual alteration (PPA) was first described by Yamaguchi in 1985. Since then, many PPA cases have been reported, and its pathophysiological mechanism has been proposed:Expand
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MAGE-D1 Regulates Expression of Depression-Like Behavior through Serotonin Transporter Ubiquitylation
The ubiquitin–proteasome system (UPS) controls the stability of most cellular proteins. The polymorphism of UPS-related genes is associated with major depression disorder, but less is known about theExpand
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Inhibition of the Protease Activity of Influenza Virus RNA Polymerase PA Subunit by Viral Matrix Protein
Influenza virus PA is a subunit of RNA‐dependent RNA polymerase. We demonstrated that PA has a unique chymotrypsin‐like serine protease activity with Ser624 as an active site. To obtain furtherExpand
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COLORECTAL CANCER Downregulation of prostaglandin E receptor subtype EP 3 during colon cancer development
Background and aims: Involvement of prostaglandin E2 (PGE2) receptors EP1, EP2, and EP4 in the formation of aberrant crypt foci (ACF) and/or intestinal polyps has been suggested. In contrast, EP3Expand
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Epidemiological Survey of Frontotemporal Lobar Degeneration in Tottori Prefecture, Japan
Background: The prevalence of frontotemporal lobar degeneration (FTLD) in Japan is unknown. An epidemiological survey study of FTLD was undertaken in Tottori Prefecture, a district in the westernExpand
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Effects of acids on neural activity elicited by other taste stimuli in the rat chorda tympani
The purpose of this study is whether the gustatory neural response of taste cell to a binary mixture with threshold concentration of acid becomes synergistic or antagonistic can be estimated from theExpand
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