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Rat CINC, a member of the interleukin-8 family, is a neutrophil-specific chemoattractant in vivo.
Rat cytokine-induced neutrophil chemoattractant (CINC) is a member of the IL-8 family and its human counterpart is MGSA/gro. Rat neutrophil responses in vitro to rat CINC, human IL-8, and humanExpand
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The neutrophil chemoattractant produced by the rat kidney epithelioid cell line NRK-52E is a protein related to the KC/gro protein.
A basic protein having chemotactic activity for neutrophils is secreted by the rat kidney epithelioid cell line NRK-52E in response to interleukin-1 beta (Watanabe, K., Kinoshita, S., and Nakagawa,Expand
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Purification and characterization of cytokine-induced neutrophil chemoattractant produced by epithelioid cell line of normal rat kidney (NRK-52E cell).
Interleukin-1 beta, tumor necrosis factor-alpha and lipopolysaccharide stimulated normal rat kidney cell line (NRK-52E) to produce a chemotactic factor for rat neutrophils. This cytokine-inducedExpand
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Inhibition of anandamide amidase activity in mouse brain microsomes by cannabinoids.
Mouse brain microsomes contain an amidase that catalyzes the hydrolysis of N-arachidonylethanolamide to arachidonic acid and ethanolamine. The enzymatic activity is dependent on the proteinExpand
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Distribution and characterization of anandamide amidohydrolase in mouse brain and liver.
Anandamide (N-Arachidonoylethanolamine) amidohydrolase catalyzing hydrolysis of anandamide was characterized in mice. The enzymatic activity was highest in the liver, followed by the brain andExpand
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Comparison in mice of pharmacological effects of delta 8-tetrahydrocannabinol and its metabolites oxidized at 11-position.
Abstract Pharmacological effects of Δ8-tetrahydrocannabinol (Δ8-THC) and its metabolites, 11-hydroxy-Δ8-THC, 11-oxo-Δ8-THC and Δ8-THC-11-oic acid were compared using mice. The cataleptogenic effectExpand
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Anandamide, an endogenous cannabinoid receptor ligand, also interacts with 5-hydroxytryptamine (5-HT) receptor.
Interactions of anandamide (N-arachidonylethanolamide), an endogenous compound for cannabinoid receptors, with the receptors for 5-hydroxytryptamine (5-HT), benzodiazepine, and gamma-aminobutyricExpand
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Oxygenation mechanism in conversion of aldehyde to carboxylic acid catalyzed by a cytochrome P-450 isozyme.
The oxygenation of an aldehyde, 11-oxo-delta 8-tetrahydrocannabinol to a carboxylic acid, delta 8-tetrahydrocannabinol-11-oic acid was catalyzed by cytochrome P-450 MUT-2 purified from hepaticExpand
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Ca2+ channel blocking effects of hirsutine, an indole alkaloid from Uncaria genus, in the isolated rat aorta.
Ca2+ channel blocking activity of hirsutine and its pharmacological features were studied. Hirsutine (10(-6) to 3 x 10(-5) M) produced a dose-dependent relaxation of the isolated rat aorta contractedExpand
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Recent advances in the metabolism of cannabinoids.
This review describes recent advances in the metabolism of cannabinoids. Cannabidiol was metabolized to cannabielsoin, 6 beta-hydroxymethyl-delta 9-tetrahydrocannabinol and an oxepine derivativeExpand
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