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Developmental changes in KCC1, KCC2, and NKCC1 mRNA expressions in the rat brain.
- C. Wang, C. Shimizu-Okabe, +6 authors K. Sato
- Biology, Medicine
- Brain research. Developmental brain research
- 15 November 2002
We investigated the expressions of KCC1, KCC2 and NKCC1 mRNAs in the developing rat brain. The neuroepithelium showed abundant KCC1 and NKCC1 mRNA expressions, while KCC2 mRNA was not detected there.… Expand
Mechanistic investigation of poly(ethylene imine)-based siRNA delivery: disulfide bonds boost intracellular release of the cargo.
- M. Breunig, Constantin Hozsa, +4 authors A. Goepferich
- Chemistry, Medicine
- Journal of controlled release : official journal…
- 25 August 2008
Poly(ethylene imine) (PEI) has gained increasing attention in the delivery of small interfering RNAs (siRNAs) into cells. In order to further optimize PEI for this application, the first goal of this… Expand
Antinociception, tolerance and withdrawal symptoms induced by 7-hydroxymitragynine, an alkaloid from the Thai medicinal herb Mitragyna speciosa.
7-Hydroxymitragynine is a potent opioid analgesic alkaloid isolated from the Thai medicinal herb Mitragyna speciosa. In the present study, we investigated the opioid receptor subtype responsible for… Expand
Antinociceptive effect of 7-hydroxymitragynine in mice: Discovery of an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa.
Mitragynine is an indole alkaloid isolated from the Thai medicinal plant Mitragyna speciosa. We previously reported the morphine-like action of mitragynine and its related compounds in the in vitro… Expand
Radiological and pathological characteristics of giant cell tumor of bone treated with denosumab
We describe a case of giant cell tumor of the proximal tibia with skip bone metastases of the ipsilateral femur in a 20-year-old man. After the neoadjuvant treatment with denosumab, plain radiographs… Expand
Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands.
- H. Takayama, H. Ishikawa, +10 authors S. Horie
- Chemistry, Medicine
- Journal of medicinal chemistry
- 20 March 2002
Mitragynine (1) is a major alkaloidal component in the Thai traditional medicinal herb, Mitragyna speciosa, and has been proven to exhibit analgesic activity mediated by opioid receptors. By… Expand
Effects of vanilloid receptor agonists and antagonists on gastric antral ulcers in rats.
- H. Yamamoto, S. Horie, M. Uchida, S. Tsuchiya, T. Murayama, K. Watanabe
- European journal of pharmacology
- 7 December 2001
Defunctionalization of capsaicin-sensitive afferent nerves by pretreatment with a neurotoxic dose of capsaicin aggravates gastric ulcers in rats. In the present study, we investigated the roles of… Expand
Pharmacological properties of magnolol and honokiol extracted from Magnolia officinalis: central depressant effects.
- K. Watanabe, H. Watanabe, Y. Gotō, M. Yamaguchi, N. Yamamoto, K. Hagino
- Planta medica
- 1 October 1983
The pharmacological properties of magnolol and honokiol, neolignane derivatives, extracted from MAGNOLIA OFFICINALIS, used in Chinese and Japanese traditional medicine, for neurosis and… Expand
Inflammatory myofibroblastic tumor (IMT) of the pancreas.
- H. Yamamoto, K. Watanabe, +5 authors T. Takenouti
- Journal of hepato-biliary-pancreatic surgery
- 1 February 2002
Inflammatory myofibroblastic tumor (IMT) is an uncommon mass lesion composed of a variety of inflammatory and other mesenchymal cells. Although IMT was originally reported in the lung, it is now… Expand
Inhibitory effect of mitragynine, an analgesic alkaloid from Thai herbal medicine, on neurogenic contraction of the vas deferens.
The effect of an indole-alkaloid mitragynine isolated from the Thai medicinal herb kratom (Mitragyna speciosa) on neurogenic contraction of smooth muscle was studied in guinea-pig vas deferens.… Expand