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Chain-length determination mechanism of isoprenyl diphosphate synthases and implications for molecular evolution.
Site-directed mutagenesis in conjunction with X-ray crystallographic studies have identified specific amino acid residues responsible for chain-length determination that represent structural features that reflect the enzyme family's evolutionary course. Expand
Isoprenyl diphosphate synthases.
Mutagenesis and X-ray crystallography data have uncovered the basic catalytic and chain length determination mechanisms of E-isoprenyl diphosphate synthases and shed light on their possible evolutionary course. Expand
Mechanisms of Steroid Oxidation by Microorganisms
Cell extracts, prepared from Nocardia restrictus, rapidly oxidize 3,4-dihydroxy-9,lO-secoandrosta-l,3,5(10)-triene9,17-dione with the consumption of 1 mole of oxygen per mole of substrate; no carbon… Expand
Mechanisms of steroid oxidation by microorganisms. IX. On the mechanism of ring A cleavage in the degradation of 9,10-seco steroids by microorganisms.
- D. Gibson, K. Wang, C. Sih, H. Whitlock
- Chemistry, Medicine
- The Journal of biological chemistry
- 20 March 1965
The possible role of a quinone intermediate in the formation of the ring fission compound has been eliminated and a reaction sequence has been proposed for the metabolism of 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene- 9,17-dione by N. restrictus. Expand
Novel lead generation through hypothetical pharmacophore three-dimensional database searching: discovery of isoflavonoids as nonsteroidal inhibitors of rat 5 alpha-reductase.
- G. S. Chen, C. S. Chang, W. Kan, C. L. Chang, K. Wang, J. Chern
- Chemistry, Medicine
- Journal of medicinal chemistry
- 10 October 2001
This investigation has demonstrated a practical approach toward the development of lead compounds through a hypothetic pharmacophore via three-dimensional database searching. Expand
A NEW ROUTE TO ESTRONE FROM STEROLS.
C-22 acid intermediates in the microbiological cleavage of the cholesterol side chain.
Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides. 8.1, 2 synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential…
A series of 2-substituted methyl 2,3-dihydroimidazo[1, 2-c]quinazolin-5(6H)-ones, synthesized as compound 1conformational rigid congeners for pharmacological evaluation as potential alpha1-adrenoceptor antagonists, found that these compounds possessed weak to no activity against the 5-HT1A receptor. Expand
ON THE MECHANISM OF RING A CLEAVAGE IN THE DEGRADATION OF 9,10-SECO STEROIDS BY MICROORGANISMS.