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The Genome of the Sea Urchin Strongylocentrotus purpuratus
The sequence and analysis of the 814-megabase genome of the sea urchin Strongylocentrotus purpuratus is reported, a model for developmental and systems biology and yields insights into the evolution of deuterostomes. Expand
Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential
Grem1 expression identifies distinct connective tissue stem cells in both the bone (OCR stem cells) and the intestine (iRSCs) that are cells of origin for the periepithelial intestinal mesenchymal sheath. Expand
RTK and TGF-β signaling pathways genes in the sea urchin genome
The sea urchin complement of genes of the RTK and TGF-β signaling pathways is qualitatively very similar to the repertoire present in vertebrates, and that these genes are part of the common genetool kit for intercellular signaling of deuterostomes. Expand
Hedgehog-responsive mesenchymal clusters direct patterning and emergence of intestinal villi
- K. Walton, Å. Kolterud, +6 authors D. Gumucio
- Medicine, Biology
- Proceedings of the National Academy of Sciences
- 10 September 2012
It is concluded that Hh signals dictate the initial aspects of the formation of each villus by controlling mesenchymal cluster aggregation and regulating cluster size. Expand
Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning.
These studies reveal a previously unrecognized association of paracrine Hedgehog signaling with several gastrointestinal patterning events involving the serosa, pylorus, and villus smooth muscle. Expand
Hedgehog signaling controls homeostasis of adult intestinal smooth muscle.
The data indicate that Hh is a critical regulator of adult intestinal smooth muscle homeostasis and suggest an important link between Hh signaling and Myocd activation, and support the idea that lowered Hh signals promote crypt expansion and increased epithelial cell proliferation. Expand
RTK and TGF-beta signaling pathways genes in the sea urchin genome.
The sea urchin complement of genes of the RTK and TGF-beta signaling pathways is qualitatively very similar to the repertoire present in vertebrates, and that these genes are part of the common genetool kit for intercellular signaling of deuterostomes. Expand
Crumbs3 Is Essential for Proper Epithelial Development and Viability
- E. L. Whiteman, Shuling Fan, +9 authors B. Margolis
- Medicine, Biology
- Molecular and Cellular Biology
- 28 October 2013
The data indicate that Crumbs3 is crucial for epithelial morphogenesis and plays a role in linking the apical membrane to the underlying ezrin-containing cytoskeleton. Expand
Repression of mesodermal fate by foxa, a key endoderm regulator of the sea urchin embryo
Three separate essential functions of the foxa gene are reported: it represses mesodermal fate in the veg2 endomesoderm; it is required in postgastrular development for the expression of gut-specific genes; and it is necessary for stomodaeum formation. Expand
Villification in the mouse: Bmp signals control intestinal villus patterning
Intestinal villus pattern in the fetal mouse is controlled by mesenchymal BMP signaling, not mechanical forces, and behaves in accordance with a reaction-diffusion Turing mechanism. Expand