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Vascular gene expression in nonneoplastic and malignant brain.
- S. Madden, B. Cook, +20 authors K. Walter
- Biology, Medicine
- The American journal of pathology
- 1 August 2004
Malignant gliomas are uniformly lethal tumors whose morbidity is mediated in large part by the angiogenic response of the brain to the invading tumor. This profound angiogenic response leads to… Expand
Scatter factor/hepatocyte growth factor protects against cytotoxic death in human glioblastoma via phosphatidylinositol 3-kinase- and AKT-dependent pathways.
We have shown recently that the multifunctional growth factor, scatter factor/hepatocyte growth factor (SF/HGF), and its receptor c-met enhance the malignancy of human glioblastoma through an… Expand
Patterns and timing of recurrence after temozolomide-based chemoradiation for glioblastoma.
- M. Milano, P. Okunieff, +4 authors D. Korones
- International journal of radiation oncology…
- 15 November 2010
PURPOSE To determine recurrence patterns of glioblastoma treated with temozolomide-based chemoradiation. METHODS Pretreatment and serial posttreatment magnetic resonance imaging scans of 54… Expand
Primary spinal cord glioma: a Surveillance, Epidemiology, and End Results database study
To characterize the overall survival (OS) and cause specific survival (CSS), and variables affecting outcome, in patients with primary spinal cord astrocytoma (SCA) and ependymoma (SCE). About 664… Expand
Plasmalemmal Vesicle Associated Protein-1 (PV-1) is a marker of blood-brain barrier disruption in rodent models
- Eveline H Shue, E. Carson-Walter, +4 authors K. Walter
- Medicine, Biology
- BMC Neuroscience
- 26 February 2008
BackgroundPlasmalemmal vesicle associated protein-1 (PV-1) is selectively expressed in human brain microvascular endothelial cells derived from clinical specimens of primary and secondary malignant… Expand
Autologous glioma cell vaccine admixed with interleukin-4 gene transfected fibroblasts in the treatment of patients with malignant gliomas
- H. Okada, F. Lieberman, +14 authors I. Pollack
- Journal of Translational Medicine
- 19 December 2007
BackgroundThe prognosis for malignant gliomas remains dismal. We addressed the safety, feasibility and preliminary clinical activity of the vaccinations using autologous glioma cells and interleukin… Expand
Plasmalemmal Vesicle Associated Protein-1 Is a Novel Marker Implicated in Brain Tumor Angiogenesis
- E. Carson-Walter, J. Hampton, +6 authors K. Walter
- Biology, Medicine
- Clinical Cancer Research
- 1 November 2005
Purpose:Plasmalemmal vesicle associated protein-1 (PV-1) is up-regulated in the endothelium of human glioblastoma. We sought to further characterize the expression pattern of PV-1 in human brain… Expand
Vascular gene expression patterns are conserved in primary and metastatic brain tumors
- Y. Liu, E. Carson-Walter, A. Cooper, Bethany N Winans, M. Johnson, K. Walter
- Biology, Medicine
- Journal of Neuro-Oncology
- 9 January 2010
Malignant primary glial and secondary metastatic brain tumors represent distinct pathological entities. Nevertheless, both tumor types induce profound angiogenic responses in the host brain… Expand
Interstitial taxol delivered from a biodegradable polymer implant against experimental malignant glioma.
Taxol is a novel antitumor agent with demonstrated efficacy against ovarian, breast, and non-small cell lung cancers in Phase II clinical trials, but which has been shown not to cross the blood-brain… Expand
A new subarachnoid hemorrhage grading system based on the Glasgow Coma Scale: a comparison with the Hunt and Hess and World Federation of Neurological Surgeons Scales in a clinical series.
OBJECTIVE Although the Hunt and Hess Scale (HHS) and World Federation of Neurological Surgeons Scale (WFNSS) are the most widely used subarachnoid hemorrhage (SAH) grading systems, neither system has… Expand