• Publications
  • Influence
Perisinusoidal stellate cells (fat-storing cells, interstitial cells, lipocytes), their related structure in and around the liver sinusoids, and vitamin A-storing cells in extrahepatic organs.
  • K. Wake
  • Biology, Medicine
  • International review of cytology
  • 1980
Publisher Summary This chapter discusses the history of the stellate cells. These cells are the integral elements of the wall of the sinusoids and that notion has introduced deep-rootedExpand
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Perisinusoidal stellate cells of the liver: important roles in retinol metabolism and fibrosis
  • R. Blomhoff, K. Wake
  • Biology, Medicine
  • FASEB journal : official publication of the…
  • 1 March 1991
In mammals, liver perisinusoidal stellate cells play an important role as a main store of body retinol (vitamin A). This fat‐soluble vitamin is essential for vision, and regulates differentiation andExpand
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Several culinary and medicinal herbs are important sources of dietary antioxidants.
We assessed the contribution of culinary and medicinal herbs to the total intake of dietary antioxidants. Our results demonstrate that there is more than a 1000-fold difference among antioxidantExpand
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Cell biology and kinetics of Kupffer cells in the liver.
Publisher Summary The study of Kupffer cells has developed rapidly and has been extended to problems concerning the origin, structure, and function of these cells in normal and pathologicalExpand
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"Sternzellen" in the liver: perisinusoidal cells with special reference to storage of vitamin A.
  • K. Wake
  • Biology, Medicine
  • The American journal of anatomy
  • 1 December 1971
The “Sternzellen” (von Kupffer, 1876) in the liver of normal animals and of those injected with excess vitamin A were examined with the light and electron microscopes. These cells were stellateExpand
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DEVELOPMENT OF VITAMIN A-RICH LIPID DROPLETS IN MULTIVESICULAR BODIES OF RAT LIVER STELLATE CELLS
  • K. Wake
  • Medicine, Biology
  • The Journal of cell biology
  • 1 November 1974
The stellate cells 1 of the liver, which were first described by von Kupffer (1876) with the gold impregnation method, are quite different from the so-called phagocytic Kupffer cells in theExpand
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Role of mesenchymal cell populations in porcine serum‐induced rat liver fibrosis
The role of liver mesenchymal cell populations in porcine serum‐induced rat liver fibrosis were studied morphologically and immunohistochemically. Fiveweek‐old rats were intraperitoneally injectedExpand
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Antiviral Activity of Glycyrrhizin against Hepatitis C Virus In Vitro
Glycyrrhizin (GL) has been used in Japan to treat patients with chronic viral hepatitis, as an anti-inflammatory drug to reduce serum alanine aminotransferase levels. GL is also known to exhibitExpand
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Maturation of rat dendritic cells during intrahepatic translocation evaluated using monoclonal antibodies and electron microscopy
Abstract Specific populations of hepatic sinusoidal cells were stained with monoclonal antibodies that recognize monocytes/macrophages (ED1), tissue macrophages (Kupffer cells) (ED2), MHC class IIExpand
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Evidence of hepatocyte apoptosis in rat liver after the administration of carbon tetrachloride.
In acute liver injury induced by the injection of CCl4, cell death has been attributed to the necrosis of hepatocytes in the centrilobular area. In the present study, we re-examined the hepaticExpand
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