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Inducible nitric oxide synthase expression after traumatic brain injury and neuroprotection with aminoguanidine treatment in rats.
TLDR
Data indicate that iNOS is expressed after moderate parasagittal fluid-percussion brain injury, in a time-dependent manner, and that inhibition of iN OS synthesis improves histopathological outcomes, and inhibition ofiNOS activation may represent a potential therapeutic strategy for the treatment of TBI.
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Role of nitric oxide in traumatic brain injury in the rat.
TLDR
These data indicate that constitutive NOS activity is affected after moderate parasagittal fluid percussion brain injury in a time-dependent manner and inhibition of activated neuronal NOS and/or enhanced endothelial NOS activation may represent a potential therapeutic strategy for the treatment of TBI.
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The role of inflammatory processes in the pathophysiology and treatment of brain and spinal cord trauma.
TLDR
Based on current data therapeutic hypothermia may protect in models of traumatic injury by modulating deleterious inflammatory processes.
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Effects of L-NAME and 7-NI on NOS catalytic activity and behavioral outcome after traumatic brain injury in the rat.
TLDR
Investigation of the effects of nitro-L-arginine-methyl ester and 3-bromo-7-nitroindazole treatment on cNOS catalytic activity and sensorimotor behavioral outcome after TBI indicates that inhibition of injury-induced elevations in neuronal NOS activity has a beneficial effect on neurological outcome after parasagittal FPI brain injury.
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Early treatment with a novel inhibitor of lipid peroxidation (LY341122) improves histopathological outcome after moderate fluid percussion brain injury in rats.
TLDR
The hypothesis that lipid peroxidation and reactive oxygen species participate in the acute pathogenesis of TBI is reinforced, as treatment delayed until 3 hours after TBI did not provide significant histopathological protection.
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Inhibitory Effect of Lutein and Pycnogenol on Lipid Peroxidation in Porcine Retinal Homogenate
TLDR
Results suggested that a combination treatment of lutein and pycnogenol is more effective for inhibiting lipid peroxidation in porcine retinal homogenate, due to efficient functional antioxidants acting in both hydrophilic and lipophilic cellular environments.
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Sevoflurane-based enhancement of phase-amplitude coupling and localization of the epileptogenic zone
TLDR
Prospective, large cohort studies are warranted to determine whether sevoflurane anesthesia can reduce the need for extraoperative, invasive evaluation of patients with drug-resistant, focal epilepsy.
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