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Relaxation and contraction responses to histamine in the human lung parenchymal strip.
The action of histamine on the human lung parenchymal strip preparation was investigated. Histamine produced relaxation at low concentrations and contraction at higher concentrations. Mepyramine, anExpand
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Formyl peptide-induced contraction of human airways in vitro.
Formylmethionylleucylphenylalanine (FMLP) is a synthetic analogue of bacterial chemotactic factors. We studied the contraction of human airway tissue in vitro by FMLP. FMLP induced aExpand
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Comparison of in vivo and in vitro responses to histamine in human airways.
The study was designed to compare in vivo responses to histamine in 14 patients prior to thoracotomy with in vitro responses to histamine of both parenchymal and bronchial tissue. Although a wideExpand
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A comparison of the contractile activity fo PGD2 and PGF2α on human isolated bronchus
Prostaglandins may be implicated in the bronchoconstriction which occurs in asthma. Prostaglandins F2α (PGF2α and D2 (PGD2) have been reported to produce bronchoconstriction in asthmatic subjects inExpand
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The calcium dependence of histamine, carbachol and potassium chloride-induced contraction in human airways in vitro.
The effect of depletion of calcium from the Krebs Henseleit (KH) solution and the addition of EDTA (1 mM) on contraction of human isolated bronchus by histamine, carbachol and potassium chlorideExpand
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AIRWAY RESPONSES IN VITRO FOLLOWING C5A DES ARG‐INDUCED HYPER‐RESPONSIVENESS IN VIVO IN RABBITS
1. The mechanism of C5a des Arg‐induced airway hyper‐responsiveness in rabbits was investigated.
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Inhibition of methoxamine-induced bronchoconstriction by ipratropium bromide and disodium cromoglycate in asthmatic subjects.
We compared the effects of pretreatment with saline, ipratropium bromide, and disodium cromoglycate (DSCG) on bronchoconstriction induced by methoxamine--an alpha-adrenoceptor agonist, in asthmaticExpand
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A comparison of the contractile activity of PGD2 and PGF2 alpha on human isolated bronchus.
Prostaglandins may be implicated in the bronchoconstriction which occurs in asthma. Prostaglandins F2 alpha (PGF2 alpha) and D2 (PGD2) have been reported to produce bronchoconstriction in asthmaticExpand
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