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Variable tandem repeats accelerate evolution of coding and regulatory sequences.
Genotype-to-phenotype mapping commonly focuses on two major classes of mutations: single nucleotide polymorphisms (SNPs) and copy number variation (CNV). Here, we discuss an underestimated thirdExpand
Intragenic tandem repeats generate functional variability
Tandemly repeated DNA sequences are highly dynamic components of genomes. Most repeats are in intergenic regions, but some are in coding sequences or pseudogenes. In humans, expansion of intragenicExpand
Domestication and Divergence of Saccharomyces cerevisiae Beer Yeasts
Summary Whereas domestication of livestock, pets, and crops is well documented, it is still unclear to what extent microbes associated with the production of food have also undergone human selectionExpand
Flocculation, adhesion and biofilm formation in yeasts
Yeast cells possess a remarkable capacity to adhere to abiotic surfaces, cells and tissues. These adhesion properties are of medical and industrial relevance. Pathogenic yeasts such as CandidaExpand
FLO1 Is a Variable Green Beard Gene that Drives Biofilm-like Cooperation in Budding Yeast
The budding yeast, Saccharomyces cerevisiae, has emerged as an archetype of eukaryotic cell biology. Here we show that S. cerevisiae is also a model for the evolution of cooperative behavior byExpand
Expression Levels of the Yeast Alcohol Acetyltransferase Genes ATF1, Lg-ATF1, and ATF2 Control the Formation of a Broad Range of Volatile Esters
ABSTRACT Volatile aroma-active esters are responsible for the fruity character of fermented alcoholic beverages such as beer and wine. Esters are produced by fermenting yeast cells in anExpand
Flavor-active esters: adding fruitiness to beer.
As they are responsible for the fruity character of fermented beverages, volatile esters constitute an important group of aromatic compounds in beer. In modern high-gravity fermentations, which areExpand
Rapid Expansion and Functional Divergence of Subtelomeric Gene Families in Yeasts
BACKGROUND Subtelomeres, regions proximal to telomeres, exhibit characteristics unique to eukaryotic genomes. Genes residing in these loci are subject to epigenetic regulation and elevated rates ofExpand
Phenotypic diversity of Flo protein family-mediated adhesion in Saccharomyces cerevisiae.
The Saccharomyces cerevisiae genome encodes a Flo (flocculin) adhesin family responsible for cell-cell and cell-surface adherence. In commonly used laboratory strains, these FLO genes areExpand
Production and biological function of volatile esters in Saccharomyces cerevisiae
The need to understand and control ester synthesis is driven by the fact that esters play a key role in the sensorial quality of fermented alcoholic beverages like beer, wine and sake. As esters areExpand